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  • 1
    Electronic Resource
    Electronic Resource
    INTERACTIONS OF VARIOUS DRUGS WITH AMPHETAMINE (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 281 (1976), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1976.tb27949.x
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  • 2
    Electronic Resource
    Electronic Resource
    Evidence against serotonin involvement in the tonic component of electrically induced convulsions and in carbamazepine anticonvulsant activity (1979)
    Springer
    Psychopharmacology 66 (1979), S. 79-85 
    Details
    ISSN: 1432-2072
    Keywords: Serotonin ; Electroshock ; Convulsions ; Carbamazepine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intraventricular injection of 5,7-dihydroxytryptamine, selective destruction of descending serotoninergic neurons by 5,6-dihydroxytryptamine or electrolytic and chemical lesions of the nucleus raphe dorsalis did not affect the electroconvulsive threshold in rats. No effect was observed after the systemic administration of drugs known to increase central serotonin transmission, such as quipazine, m-chlorophenylpiperazine, and moderate doses of d-fenfluramine, whereas p-chlorophenylalanine, an inhibitor of serotonin synthesis, decreased seizure susceptibility. The anticonvulsant activity of carbamazepine was not modified in animals with the same experimental lesions. The results, in relation to the high selectivity of the experimental procedures employed to deplete brain and spinal cord serotonin, do not bear out any involvement of serotonin in the tonic component of electrically induced convulsions or in the action of carbamazepine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431994
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  • 3
    Electronic Resource
    Electronic Resource
    Morphine analgesia in grouped and isolated rats (1975)
    Springer
    Psychopharmacology 41 (1975), S. 11-14 
    Details
    ISSN: 1432-2072
    Keywords: Morphine Analgesia ; Isolation in Rats ; Muricidal Behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of long-term isolation of young adult male rats on the analgesic effects of morphine were investigated. Isolated rats developed altered patterns of behavior, including muricidal behavior in some animals. Analgesic activity of morphine was assessed with both the tail compression and the hot plate methods. The results indicate that chronically isolated rats, whether developing muricidal behavior or not, show no alteration in either pain thresholds or in their response to morphine-induced analgesia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421298
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  • 4
    Electronic Resource
    Electronic Resource
    Dependence to morphine in differentially housed rats (1975)
    Springer
    Psychopharmacology 41 (1975), S. 15-18 
    Details
    ISSN: 1432-2072
    Keywords: Morphine ; Dependence ; Abstinence Syndrome ; Social Isolation ; Rats ; Chronic Isolation ; Narcotics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although the effects of differential housing, particularly isolation, on the action of several classes of pharmacological agents have been studied, little attention has been given to this factor in regard to narcotics. The present study involves the effects of long-term social isolation on dependence to morphine produced by pellet implants in rats. When abstinence was precipitated with naloxone, isolated rats demonstrated less jumping and less diarrhea than grouped rats. No differences were found in other signs. In addition, the differences were seen both in isolates developing muricidal behavior and those not developing this behavioral pattern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421299
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  • 5
    Electronic Resource
    Electronic Resource
    Antinociceptive action of quipazine: Relation to central serotonergic receptor stimulation (1976)
    Springer
    Psychopharmacology 46 (1976), S. 219-222 
    Details
    ISSN: 1432-2072
    Keywords: Quipazine ; Antinociceptive action ; Serotonin ; Methergoline ; Midbrain raphe lesions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Quipazine, a serotonin receptor stimulant, inhibited the response of rats to painful stimuli in two methods currently used to measure antinociception in these animals: the hot plate and tail compression test. The antinociceptive action was observed with doses ranging from 5 to 20 mg/kg i.p. according to the test situation. The effect was significantly antagonized by a pretreatment with methergoline, a potent serotonin antagonist. An electrolytic lesion placed in the nucleus raphe medianus, which produced a marked decrease of serotonin in the forebrain did not, or only slightly, affected the effect of quipazine, depending on the method used to measure antinociception. It is suggested that quipazine can produce antinociceptive action in rats by interacting with a serotonergic mechanism. The action appears to be due mainly to a direct action on postsynaptic serotonin receptors, although a presynaptic component can also contribute to the effect of quipazine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421395
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  • 6
    Electronic Resource
    Electronic Resource
    m-Chlorophenylpiperazine: A central serotonin agonist causing powerful anorexia in rats (1979)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 308 (1979), S. 159-163 
    Details
    ISSN: 1432-1912
    Keywords: Serotonin ; Receptor stimulation ; Metachlorophenylpiperazine ; Anorexia ; Catecholamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Meta-chlorophenylpiperazine inhibited serotonin and noradrenaline uptake by synaptosomes to the same extent with IC50 of 1.3×10−6 M and 5.8×10−6 M respectively. Dopamine uptake was lesss affected by meta-chlorophenylpiperazine (IC50 of 2.2×10−5 M). Unlike d-amphetamine and d-fenfluramine, the drug did not significantly increase monoamine release in synaptosomal preparations. On the other hand, metachlorophenylpiperazine showed an IC50 of 620 nM in displacing 3H-5HT binding to brain membranes. Meta-chlorophenylpiperazine produced a dose-dependent reduction of food intake and this effect was prevented by a pretreatment with methergoline, a serotonin antagonist. The effect of metachlorophenylpiperazine was not modified by an intraventricular injection of 6-hydroxydopamine, electrolytic lesions of nucleus medianus raphe or ventral noradrenergic bundle, nor by a pretreatment with penfluridol, propranolol or phentolamine. The data suggest that the decrease of food intake induced by metachlorophenylpiperazine depends on its ability to act as a serotonin agonist in the brain. The specificity of the effects on serotonin suggests that this compound could prove an important tool for studies aimed at elucidating the functional role of serotonin in the central nervous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499059
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