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  • 1970-1974  (5)
  • 1965-1969  (5)
  • Life and Medical Sciences  (9)
  • Beta-Adrenergic Antagonist  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Beta-adrenergic receptor involvement in the mediation of learned taste aversions (1972)
    Springer
    Psychopharmacology 26 (1972), S. 79-83 
    Details
    ISSN: 1432-2072
    Keywords: Conditioned Taste Aversions ; Beta-Adrenergic Agonist ; Beta-Adrenergic Antagonist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Drug-induced stimulation or blockade of beta-adrenergic receptors in the lateral hypothalamus has been reported to enhance or reduce, respectively, the normally supressive affect of quinine adulteration on sweet milk consumption in rats. Subsequently, it was hypothesized that the beta-receptors may function analogously in the mediation of learned taste aversions. In order to test this hypothesis we conditioned rats to avoid a preferred aqueous solution of saccharin (0.1% w/v) by pairing it with a toxic injection of 0.4 molar lithium chloride (10 ml/kg i.p.). Three days later the rats were re-exposed to saccharin water 30 min after receiving a ventricular injection of either the beta-adrenergic agonist dl-isoproterenol hydrochloride (18 Μg) or the beta adrenergic antagonist dl-4-[2 hydroxy-3-isopropylaminopropoxy]-indole (32 Μg). As predicted, the beta-agonist further enhanced the avoidance of saccharin among animals already conditioned to avoid it, while the blocking agent attenuated the learned aversion. However, the influence of the drugs on drinking was similar among unconditioned control animals suggesting that their affects were independent of prior learning.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421921
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  • 2
    Electronic Resource
    Electronic Resource
    Gross and microscopic observations on the communicating branch of the facial nerve to the lesser petrosal nerveThis investigation was partially supported by United States Public Health Service grant FR 05388. (1967)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 158 (1967), S. 257-261 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The contents of the facial canal (first and second parts of the facial nerve, and geniculate ganglion), the tympanic plexus, the greater and lesser petrosal nerves, and all intervening connections were dissected in 40 cadavers. This entire nerve complex was removed in 30 cases, and in parts in ten cases, dehydrated, and stained with Sudan Black B or Protargol. A constant communication from the second part of the facial nerve, the geniculate ganglion, or the greater petrosal nerve was observed to pass to the lesser petrosal nerve in all dissections. A review of the literature indicates other points relative to the exchange of autonomic fibers between the facial and glossopharyngeal nerves.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091580304
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Nerve cells in the extracranial portion of the hypoglossal nerve in human fetuses (1968)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 162 (1968), S. 517-522 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The hypoglossal nerve with its communicating branches between the hypoglossal canal and its terminal rami was removed in toto from 11 human fetuses varying from 63 to 342 mm C.R. length. Serial sections were stained with luxol fast blue or impregnated with silver nitrate or protargol according to Bodian's method. The total number of nerve cells varied from 10 to 82 on the right side and from 6 to 60 on the left. Morphologically these cells resembled the cells in the inferior ganglion of the vagus nerve and they were always observed within the communicating rami between this ganglion and the hypoglossal nerve. The possibility of migration of these cells from the inferior ganglion of the vagus to the hypoglossal nerve and their relationship to the proprioceptive innervation of the tongue are discussed.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091620414
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  • 4
    Electronic Resource
    Electronic Resource
    The intermediate root of the trigeminal nerve in the dog (Canis familiaris) (1971)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 169 (1971), S. 697-703 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The intermediate root of the trigeminal nerve in the dog has been investigated both macroscopically and microscopically. Sixty-two trigeminal complexes (trigeminal ganglion, trigeminal roots and the portion of the pons to which the roots were attached) in the dog were dissected out and removed. Each of the complexes was fixed in 10% formalin, dehydrated and embedded in paraffin. The paraffin blocks were cut serially at 10 μ. Every other slide was either stained with Luxol Fast Blue or impregnated with Bodian's silver method. In all cases, between the motor and sensory roots an intermediate root composed of one distinct rootlet was identified. Most frequently the intermediate root was attached to the pons from 0.5 to 3.0 mm lateral to the motor root and rostral to the sensory root from 0.5 to 2.0 mm. From its pontine attachment the intermediate root extended anteromedially for a distance of from 2.0 to 5.0 mm before it became incorporated in the lateral aspect of the free motor root. Closer to the trigeminal ganglion the motor root and the intermediate root fused with the expanding sensory root. The fibers in the intermediate root ranged from 1.5 to 7.5 μ in diameter with the majority of fibers (60 to 70%) having a diameter of from 4.0 to 6.0 μ. Approximately 10% of the fibers were unmyelinated. The total number of fibers in the intermediate root varied from 170 to 416 with an average of 266 fibers. The morphological data obtained in an experimental animal such as presented in this paper may provide a basis for future experimental work on the clarification of the functional role of the trigeminal intermediate root.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091690408
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  • 5
    Electronic Resource
    Electronic Resource
    Embryonic vertebrate central nervous system: Revised terminology (1970)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 166 (1970), S. 257-261 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The layers and cells of the early developing central nervous system lack direct counterparts in the adult and must be designated by a special terminology. The inconsistent and inaccurate language now in use leads to misunderstanding and a revision is proposed in which the four fundamental zones are termed the ventricular, subventricular, intermediate, and marginal zones. Each is defined according to the form, behavior, and fate of its constituent cells. All neurons and macroglia of the central nervous system can be derived from these developmental zones.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091660214
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  • 6
    Electronic Resource
    Electronic Resource
    Inhibition of cellular adhesiveness by sulfhydryl blocking agents (1971)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 78 (1971), S. 153-157 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Rat hepatoma cells rapidly adhered to the polystyrene surfaces of culture bottles. The adhesiveness of the cells was inhibited by sulfhydryl blocking reagents including mercurials, arsenicals, and alkylating agents. Inhibition was prevented, and in some cases reversed, by the addition of dithiothreitol to the adhesive medium. The current model explaining cellular adhesion is discussed in the light of these observations.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040780119
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  • 7
    Electronic Resource
    Electronic Resource
    Factors influencing hematopoietic spleen colony formation in irradiated mice. IV. The effect of erythropoietic stimuliThis investigation was supported by a research grant (AM-04489) and a graduate training grant (2A-5098) from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland. (1968)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 71 (1968), S. 65-75 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: A variety of erythropoietic stimuli influenced the number of endogenous spleen colonies in irradiated mice and the number of transplantable colony forming cells in the spleen and marrow of unirradiated mice.Bleeding was the most effective stimulus. Bleeding before irradiation resulted in a 30-fold increase in endogenous spleen colonies and in increases in spleen weight, spleen iron and iododeoxyuridine uptake and volume of packed red cells ten days after irradiation. Bleeding unirradiated mice produced a 10-fold increase in the number of transplantable colony forming cells in the spleen and a slight decrease in the total number in the humerus. Bleeding before irradiation resulted in a significant reduction in 30-day post irradiation deaths, an effect abolished by splenectomy. Plasma from bled mice induced an increase in endogenous colonies when injected before irradiation into normal mice.Injection of erythropoietin, testosterone or testosterone plus cobalt induced effects which were, in general, qualitatively similar to those of bleeding, although they were less effective quantitatively. Except for a slight effect induced by ten injections of erythropoietin, post-irradiation stimulation in normal mice proved ineffective. Erythropoietin increased colony numbers and spleen iron uptake when given after irradiation to hypertransfused mice.The results of these studies do not support the concept that the colony forming cell and the erythropoietin sensitive cell are separate entities.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040710109
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  • 8
    Electronic Resource
    Electronic Resource
    Factors affecting the production of glutamine in cultured mouse cells (1971)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 77 (1971), S. 135-144 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Glutamine synthetase activity of NCTC clone 929 mouse cells (strain L) was studied as a function of the prior nutritional experience of the cells. Small enzyme increases were recorded in response to either glutamine depletion or chronic serum supplementation of the growth medium. Somewhat greater increases resulted from the administration of cortisol or certain other steroids, particularly if the hormone treatment was combined with glutamine withdrawal. High concentrations of glutamate in the medium did not augment the glutamine synthetase content of the cells and even caused an apparent decrease in it. The presence of glutamine in the culture medium resulted in a fairly rapid rate of disappearance of the glutamine synthetase of previously induced cells. The data suggest that glutamine and cortisol act independently on the cells in regulating the level of the enzyme.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040770203
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  • 9
    Electronic Resource
    Electronic Resource
    Decreased neutrophils and megakaryocytes in anemic mice of genotype W/Wv (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 73 (1969), S. 25-30 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The concentration of neutrophils and megakaryocytes was determined in the marrow of anemic mice of genotype W/Wv and their normal (+/+) litter mates. In all groups studied, the humerus of W/Wv mice contained significantly less neutrophils and megakaryocytes than did normal animals. Blood neutrophil concentration was less in all groups of W/Wv mice but in only one group which was the youngest group studied, did this value differ significantly from normal.The blood and marrow neutrophil response to endotoxin was similar in W/Wv and “+/+” animals. This suggests that the neutrophilic system of W/Wv mice responds to this stimulus in a relatively normal manner, much as their erythroid system responds to hypoxia, and androgens.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040730104
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  • 10
    Electronic Resource
    Electronic Resource
    The metabolism of L-glutamate and L-5-Carboxypyrrolidone by mouse cells (NCTC clone 929) under conditions of defined nutritionThis investigation was supported in part by Public Health Service Research Grant A-4715 from the National Institute of Arthritis and Metabolic Diseases, and in part by a grant to The Jackson Laboratory from The John A. Hartford Foundation. (1966)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 67 (1966), S. 383-398 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The utilization of L-glutamate by clone 929 mouse cells growing in a synthetic medium, MAL 294/2, was studied with the aid of carbon-14 labeled L-glutamate. The rate of consumption of extracellular glutamate was rapid even though the extracellular concentration of this substance has been found to remain constant or to increase. The rate of uptake during an interval of otpimal growth was calculated to be approximately 42 mμmoles/mg of cell protein per hour.Among the metabolic products that are derived from the carbon of glutamate and secreted from the cells are carbon dioxide, lactic acid, proline, alanine, alpha-ketoglutaric acid and 5-carboxypyrrolidone. Aspartic acid, although produced by the cells in amounts sufficient to meet the needs for growth, does not appear as an extracellular product of glutamate metabolism. Extracts of L cells were found to exhibit four times as much glutamic-oxaloacetic as glutamic-pyruvic transaminase activities. Failure to secrete aspartic acid must not be due to a deficiency in the transaminase. The transaminase concentrations are apparently not affected by variations in the concentrations of aspartic acid and alanine in the medium, both of which are absent from MAL 294/2.5-Carboxypyrrolidone, although produced from L-glutamate by L cells, is metabolically inert in this system. Likewise, mouse fetal lung cells, cultured in a similar way, use glutamic acid as extensively as L cells and fail to metabolize exogenous 5-carboxypyrrolidone.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040670304
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