ISSN:
0003-276X
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
Wistar strain albino rats were fed a folic acid free diet with added folic acid antagonists (x-methyl folic acid and 9-methyl pteroylglutamic acid) for a 48-hour period beginning on day 8 and ending on day 10 of gestation. The period of deficiency was terminated by an injection of 500 μg of folic acid in water. If the injection was not made, most animals resorbed their litters. Fetuses were excised from days 16 through 20, processed routinely, decalcified, if necessary, embedded in paraffin, serially sectioned, and stained. Newborns were treated similarly. Hydrocephalus was the only defect observed in the treated animals. The serial sections demonstrated an occluded or extremely stenotic aqueduct of Sylvius in every hydrocephalic animal examined. The stenosis was seen to be present as early as the sixteenth day of gestation, and occlusion was observed in 17-day-old animals. It is concluded that the defect predisposing to hydrocephalus induced by folic acid deficiency in this strain of rats is extreme stenosis or complete occlusion of the aqueduct of Sylvius.
Additional Material:
2 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/ar.1091510310
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