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14 C-Catecholamine Synthesis in Mouse Brain during Morphine Withdrawal (1972)

ROSENMAN, S. J. ; SMITH, C. B.

[s.l.] : Nature Publishing Group

Nature 240 (1972), S. 153-155

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] Brain contents of 14C-dopamine and 14C-noradrenaline were determined 40 min after the injection of 14C-tyrosine (55 ug kg-1; specific activity, 410 mCi/mmol, uniformly labelled, New England Nuclear Corporation) into the tail vein of the female albino mouse (20-30 g). Maximum incorporation of ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/240153a0

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Antagonism of locomotor suppressant effects of reserpine in mice (1962)

Smith, C. B. ; Dews, P. B.

Springer

Psychopharmacology 3 (1962), S. 55-59

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ISSN: 1432-2072

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary In this study a direct quantitative comparison has been made of the effects of 5-HTP and DOPA on locomotor activity of normal control mice and of mice treated with either reserpine or iproniazid, or with reserpine and iproniazid together. Thirty-four groups of female albino mice and ninety-six groups of male albino mice were used. DOPA, but not 5-HTP, restored co-ordinated locomotor activity to mice treated either with reserpine or with reserpine and iproniazid. Treatment with reserpine enhanced the effects of DOPA in increasing the activity of iproniazid-treated mice. DOPA alone suppressed locomotor activity of normal control mice. The effect of 5-HTP on normal mice did not differ significantly from that of saline.