Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 286 (1974), S. 195-210 
    ISSN: 1432-1912
    Keywords: Cats ; Cardiac Glycosides ; Inotropic Action ; Distribution ; Protein Binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The tissue distribution and the positive inotropic effect of α- and β-methyl-digoxin, digoxin, and digitoxin were investigated in cats under pentobarbital anaesthesia, the emetic effect of β-methyl-digoxin and digoxin in unanaesthetized animals. 1. The distribution volume calculated by dividing the injected dose by the concentration in the plasma water after 60 min decreased in the order digitoxin 〉 β-methyl-digoxin ≥ α-methyl-digoxin 〉 digoxin. 2. The distribution coefficients between tissue and plasma water decreased for all glycosides in the order kidney 〉 liver 〉 heart 〉 diaphragm 〉 erythrocytes 〉 perirenal fat 〉 brain. 3. α-Methyl-digoxin and digoxin were metabolized to a larger extent than were β-methyl-digoxin and digitoxin. 4. 200 nmoles/kg digoxin produced arrhythmias, whereas equimolar doses of the other glycosides were well tolerated. 5. Except for α-methyl-digoxin, there was a close relation between the increase in dp/dt max and the concentration in the plasma water 60 min after the injection. The differences in the equieffective doses of β-methyl-digoxin, digoxin, and digitoxin can therefore be explained by the differences in tissue distribution. 6. Although higher concentrations of β-methyl-digoxin than of digoxin were found in the brain, there was no difference in the central activity of the two glycosides.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...