ISSN:
1436-2813
Keywords:
ovariectomy
;
androgen
;
DMBA
;
mammary tumor
;
adenocarcinoma
;
histological pattern
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effect of hormonal manipulation on the mammary tumor growth and on its histological changes were studied using DMBA-induced mammary tumor in rats. Ovariectomy resulted in regression of 83 per cent of the mammary tumors examined but most of the tumors regressed began to grow again after 7 to 8 weeks. The administration of androgen had inhibitory effect on the growth in 75 per cent of the tumors. The histology of the growing tumors before ovariectomy exhibited either a poorly differenciated or a tubulopapillary carcinoma. Histological features changed to atrophic cystic epithelium by ovariectomy and regrowing tumors following the post-ovariectomy remission tended to show reversion to primary features.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02468777
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