ISSN:
1432-2072
Keywords:
Noradnamine
;
Tetrabenazine
;
Locomotor Activity
;
Drug Interactions
;
Statistical Analysis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A method for the measurement of drug interactions on locomotor activity in mice has been described. The experiments were designed on a factorial basis and the data obtained were subjected to variance analysis. Using the principles described, the effects of various drugs on the hypoactivity induced by noradnamine or tetrabenazine were studied. Twenty potential drug interactions were examined, but only seven of these exhibited statistically significant interaction. Tetrabenazine hypoactivity was antagonised by nortriptyline, amitriptyline, nialamide and noradnamine. The latter also potentiated the effect of a low dose of tetrabenazine. Hypoactivity induced by noradnamine was antagonised by amitriptyline and nortriptyline, potentiated by atropine but unaffected by nialamide. The significance of these findings is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00412674
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