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  • 1970-1974  (1)
  • 1935-1939  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    THE UPTAKE OF γ-[3H]AMINOBUTYRIC ACID BY SLICES FROM VARIOUS REGIONS OF RAT BRAIN AND THE EFFECT OF LITHIUM (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 20 (1973), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Slices from various regions of rat brain, incubated at 25°C, rapidly accumulate [3H]GABA from the surrounding medium until after 60min tissue:medium ratios as high as 300 may be achieved. Kinetic analysis has demonstrated two distinct uptake systems for GABA in all the brain regions examined. One system has a relatively high substrate affinity (Km= 1.2 ± 10-5 M) while the other has a lower affinity (Km= 4 ± 10-4 M). Studies at low GABA concentration (5 ± 10-8 M), as well as estimates of maximum velocities, have shown that the distribution of the high affinity uptake system is heterogeneous. Cortex, hypothala mus, midbrain and hippocampus have relatively high uptake rates while the striatum, cerebellum and pons and medulla have a lower uptake rate. Maximum velocities for the low affinity uptake system show much less regional variation.Lithium, either added to the incubation medium or fed to rats, had no effect on the uptake of GABA by cortical slices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1973.tb12150.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Stable Sulfur Dithiocyanate (1938)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 60 (1938), S. 2614-2615 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01278a017
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    Paper (German National Licenses)
    Fulltext
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