ISSN:
1432-8798
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Several double-stranded complexes of copolyribonucleotide of inosinic and guanylic acids with polyribocytidylic acid (poly IG∶C) were found to possess interferon inducing activity stronger than poly I∶Cin vivo, Their activity increased in parallel with increase in the ratio of guanine base to hypoxanthine base in these copolymers as far as double-strand formation was observed with polyribocytidylic acid. Many other combinations of copolyribonucleotide with homopolyribonucleotide were also investigated, and several of them were found to induce interferon. However, the interferon inducing effects of these combinations including complementary base-pairings of hypoxanthine and cytosine increased in parallel with the length of the base-pairings, thus approaching to that of poly I∶C. It is, therefore, supposed that the activity of poly IG∶ C is somewhat different from poly I∶C and that those of other combinations owe to the essential structure of poly I∶C. Furthermore, kinetics of interferon induction, cross tolerance to reinduction, and antiviral effectsin vivo of poly IG∶C and poly I∶C were studied.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01241712
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