ISSN:
1432-2072
Keywords:
Chlordiazepoxide
;
Caffeine
;
Aggression
;
Rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Rats were given chlordiazepoxide (CDP) before testing in the Ulrich and Azrin shock-induced aggression paradigm for 10 consecutive days. CDP significantly decreased shock-induced aggression but fighting rates did not increase over the course of testing with the drug. Thus any tolerance to the general behavioral depressant effect of the drug either did not occur, or the behavioral depression was not responsible for the reduction in aggression. Another group was administered no drug, caffeine, and CDP, alone or in combination in a spontaneous activity test. CDP suppressed activity, caffeine increased activity and the two drugs in combination had antagonistic effects. The same drugs were used alone or in combination to measure their effects on shock-induced aggression. CDP suppressed aggression, caffeine also suppressed aggression and the two drugs together had additive effects. It was concluded that CDP-induced general behavioral depression is not responsible for suppression of aggression but more likely the property of CDP as a c-AMP phosphodiesterase inhibitor is responsible for the anti-aggression effect.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00421223
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