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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 51 (1973), S. 571-573 
    ISSN: 1432-1440
    Keywords: dopamine ; haloperidol ; arterial pO2 ; pulmonary arterio-venous anastomoses ; dopamine-receptor ; Dopamin ; Haloperidol ; arterieller Sauerstoffdruck ; pulmonale arteriovenöse Anastomosen ; Dopaminreceptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Dopamininfusion bewirkt eine deutliche Abnahme des arteriellen Sauerstoffdruckes. Diese Entwicklung einer arteriellen Hypoxämie muß am ehesten durch Eröffnung pulmonaler arteriovenöser Anastomosen erklärt werden. Wie die Dopamin-bedingte Vasodilatation im Nieren-und Coronargefäßsystem, kann die Dopamin-bedingte arterielle Hypoxämie durch Vorbehandlung mit Haloperidol blockiert werden. Somit sind auch in der Lungenstrombahn Dopaminspezifische Receptoren anzunehmen, die möglicherweise die Öffnung arteriovenöser Anastomosen regulieren.
    Notes: Summary Dopamine infusion regularly is accompanied by a distinct decrease of arterial pO2. An opening of pulmonary arterio-venous anastomoses is suggested to be the cause of this arterial hypoxaemia. This dopamine effect is attenuated by pretreatment with haloperidol, thus resembling the dopamine-induced vasodilatation seen in the coronary and renal vascular bed. These results support the hypothesis that dopamine is also acting upon a specific receptor in the pulmonary vascular bed which probably regulates the opening of arterio-venous anastomoses.
    Type of Medium: Electronic Resource
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