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  • 1970-1974  (10)
  • Biochemistry and Biotechnology  (4)
  • Life and Medical Sciences  (4)
  • Analytical Chemistry and Spectroscopy  (2)
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Year
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  • 1
    Electronic Resource
    Electronic Resource
    Estimation of parameters in population models for Schizosaccharomyces pombe from chemostat data (1972)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 14 (1972), S. 915-938 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The integro-differential growth model of Eakman, Fredriekson, and Tsuehiya has been employed to fit cell size distribution data for Schizosaccharomyces pombe grown in a chemostat under severe product inhibition by ethanol. The distributions were obtained with a Coulter aperture and an electronic system patterned after that of Harvey and Marr. Four parameters - mean cell division size, cell division size standard deviation, daughter cell size standard deviation, and a growth rate coefficient - were calculated for models where the cell growth rate was inversely proportional to size, constant, and proportional to size. A fourth model, one where sigmoidal growth behavior was simulated by two linear growth segments, was also investigated. Linear and sigmoidal models fit the distribution data best. While the mean cell division size remained relatively constant at all growth rates, standard deviation of division size distribution increased with increasing holding times. Standard deviation of the daughter size distribution remained small at all dilution rates. Unlike previous findings with other organisms, the average cell size of Schizosaccharomyces pobme increased at low growth rates.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260140605
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  • 2
    Electronic Resource
    Electronic Resource
    Properties of ribulose diphosphate carboxylase immobilized on porous glass (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 16 (1974), S. 1507-1516 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Ribulose-1,5-diphosphate carboxylase from spinach has been bound to arylamine porous glass with a diazo linkage and to alklamine porous glass with glutaraldehyde. Stability at elevated temperatures and responses to changes of pH and ribulose-1,5-diphosphate, Mg2+, and dithiothreitol concentrations were not significantly different from the soluble enzyme, though stability at 4°C was somewhat improved.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260161107
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  • 3
    Electronic Resource
    Electronic Resource
    Symbiotic growth of Acetobacter suboxydans and Saccharomyces carlsbergensis in a chemostat (1972)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 14 (1972), S. 75-92 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The bacterium Acetobacter suboyxdans and the yeast Saccharomyces carlsbergensis have been grown together on a synthetic medium in a chemostat. Mannitol, the only carbon source fed to the fermenter, is oxidized by the bacteria to fructose. The yeast, which cannot attack mannitol, breaks down the fructose nearly completely. Eight steady states and five transitory periods after changes in flow rate have been analyzed to study the kinetics of the mixed culture. Separate cell concentrations were determined by a modified Coulter counter apparatus. Both sugars were monitored. Both bacteria and yeast may be modeled using Monod's equation, the latter with some deviations. The yeast is unable to grow beyond the washout point of the bacteria, even though its maximum growth rate is much higher. The yield of both organisms decreases with increasing dilution rate, as does their average cell size. After step changes in dilution rate, repeated oscillations of both sugar and cell concentrations usually occur before steady-state conditions are reattained. They are generally in phase, with no definite sign of a lag. Oscillations of yeast and fructose concentrations are more pronounced. Periods average about 6 hr and are not correlated with fermentation conditions or equipment variables. Repeated oscillations are not found after step-downs in pure cultures of A. suboxydans, leading to the conclusion that the instability in mixed cultures may be caused by a feedback mechanism from the yeast to the bacteria.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260140108
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  • 4
    Electronic Resource
    Electronic Resource
    Stability of commensalistic systems (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 16 (1974), S. 1373-1392 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The response of two-species commensalistic systems in a chemostat has been investigated after perturbations in steady state conditions and after step changes in dilution rate. The system is inherently stable with not more than three overshoots and undershoots possible. More complicated commensalistic systems are less stable, with limit cycle response occurring after dilution rate changes when feedback inhibition and feedforward activation occurs. In general variation of feedback parameters is more effective in changing the behavior of the systems than variation of feedforward parameters. Limited agreement with the experimental data of Chao and Reilly was obtained.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260161006
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of endotoxin on murine stem cellsThis study supported in part by grants from National Heart and Lung Institute HL 7542, and HL 5600 and from the General Research Branch NIH FE 5587. (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 82 (1973), S. 239-244 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Previous studies showed that after 5 μg of Salmonella typhosa endotoxin there was an increase in colony stimulating factor temporally related to a fall in murine marrow in vitro colony forming cells (CFC). This was followed by differentiation along the marrow granulocytic pathway. The present studies showed that after 5 μg of endotoxin the peripheral blood CFC fell by approximately 50% at one hour, rose to a level ten fold that of control at six hours and then returned to control values by 48 hours. There was a progressive increase in the number of splenic CFC to ten fold that of control from 24 to 72 hours after endotoxin. These data imply a migration of CFC from the marrow to the spleen along with an in-situ increase in splenic CFC. Thus, either migration or differentiation may explain the fall in marrow CFC after endotoxin.Spleen colony forming units (CFU) in the marrow were measured by a transplantation technique and the transplantation fraction (f Fx) determined. A decrease in marrow CFU at 24 hours after endotoxin was secondary to a change in the f Fx. from 11.1% to 7.6%. There was however, an increased percentage of CFU in DNA synthesis in the interval of 6-48 hours after endotoxin, as judged by the hydroxyurea technique. As the marrow CFC fell within 20 minutes of endotoxin administration, the data suggest the CFC may be affected initially and that changes in the generative cycle of the CFU may be of a secondary nature.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040820212
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  • 6
    Electronic Resource
    Electronic Resource
    Uridine uptake and its intracellular phosphorylation during the cell cycle (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 82 (1973), S. 267-275 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The rate of 5-3H uridine uptake into Chinese hamster V79 cells and the rate of its incorporation into RNA increase tenfold during the cell cycle. Both reactions exhibit the same apparent Km(1.7 × 10-5 M). Chromatography of acid-soluble material from cells incubated with 5-3H uridine (0.25 μM) at different times of the cell cycle revealed that intracellular uridine was rapidly phosphorylated at all times, even though cells in late S and G2 take up roughly ten times as much uridine as cells in G1. Uridine kinase activity in synchronized cells increases about two and one-half-fold during the same time period, and in exponentially growing cells is not saturated until the external uridine concentration is raised above 200 μM. It is concluded that the change in uridine kinase activity during the cell cycle is not responsible for the tenfold increase in the rate of uridine transport, and that these two processes are independently regulated.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040820215
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  • 7
    Electronic Resource
    Electronic Resource
    Autoradiographic localization of 3H-testosterone or its metabolites in the neonatal rat brainThis research was supported by PHS grant R01 NS09914, grant HD-03110 from the National Institute for Child Health and Human Development to the Biological Sciences Research Center of the Hild Development Research Institute, and a grant from the Rockefeller Foundation to the Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill, North Carolina. (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 140 (1974), S. 589-594 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The distribution of neurons which concentrate testosterone or its metabolites in the brain of 2-day old female rats was determined using autoradiography. A specific topographic pattern of neurons which concentrate testosterone or its metabolites was obtained similar, but not identical, to the one found in adult male rats. The demonstrated sites of nuclear uptake and retention of testosterone or its metabolites by specific neurons in the neonatal brain probably provide the anatomical substrate for sexual differentiation of the brain.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001400411
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  • 8
    Electronic Resource
    Electronic Resource
    Surface structures of the antennular flagella of the hermit crab Pagurus alaskensis (Benedict): A light and scanning electron microscopy study (1974)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 144 (1974), S. 195-215 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The surface structures of the antennular flagella of Pagurus alaskensis are described in detail. Attention is directed towards the surface morphology of two types of possible sensilla: (1) exoskeletal pores (1.0-3.0 μm in diameter); (2) setae of various kinds. In addition, small (0.1-0.2 μm) pits occur in the exoskeleton which are not considered to be sensory in function. The exoskeletal pores are found at fairly specific locations on both the inner and outer flagella, particularly on the short segments of the outer flagella. Neither the inner nor the outer flagella are bilaterally symmetrical with respect to their setal armature. On the outer flagellum six groups of setae may be distinguished: lateralmesial; dorsal; ventral; accessory; aesthetasc; setae of the distal segment. On the inner flagellum setae of the mesial and lateral rows form distinctive groups. The morphology, orientation and locations of all the flagellar setae are defined and where possible the numbers of the various morphological types within the specific setal groups are given. It is noteworthy that many setal types have obvious apical pores and yet no pores could be found in the chemoreceptive aesthetasc setae. The functions of the various setae are discussed in relation to their topographical position and to existing electrophysiological and behavioral data. Some suggestions are made about future experiments to demonstrate the central connections of specific sensilla or groups of sensilla and to show their significance in the whole animal.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051440206
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  • 9
    Electronic Resource
    Electronic Resource
    Mass spectral fragmentations of aminoketones in which charge is not localized exclusively on nitrogen (1970)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 3 (1970), S. 1307-1315 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The low resolution mass spectra of α-dimethylaminoacetophenone and γ-dimethylaminobutyrophenone are compared to those of δ-methylhexanophenone and dimethyl n-butylamine as well as to those of α-dimethylaminoacetonitrile and γ-dimethylaminobutyronitrile. Analysis indicates that significant fractions of the fragmentations of the aminoketones are directed by the carbonyl. In particular, McLafferty rearrangement of the γ-aminoketone is favored over α-cleavage from nitrogen at ionizing voltages below 15 eV. Although the overall fragmentation patterns are presumably determined both by the distribution of charge and by the relative rates of the fragmentation processes available to the two ionized groups, the intrinsic rates for α-cleavage at ionized nitrogen and at ionized carbonyls appear to be very similar. Kinetic analysis suggests that 26% of the charge resides on the carbonyl in the γ-aminoketone molecular ion. The extent of delocalization of charge in any aminoketone may be partially controlled by the extent of spatial overlap of the two groups. Correlations of mass spectral behavior with photochemical behavior are thus limited because electronic excitation is more localized in the lowest excited states of molecules than charge is in electron-impact produced molecular ions.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210031010
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  • 10
    Electronic Resource
    Electronic Resource
    Ultra long range 19F—19F spin-spin coupling (1974)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 6 (1974), S. 126-127 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The observation of long range (10-14 bond) spin-spin coupling between fluorine nuclei (which are very far apart in space) is used to provide information about electronic interactions in bridged dinuclear aromatic compounds.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270060215
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