ISSN:
1432-2072
Keywords:
δ 9-Tetrahydrocannabinol
;
Cannabinol
;
Cannabidiol
;
Interaction
;
Hexobarbitone
;
Motility
;
Food Intake
;
Water Intake
;
Body Temperature
;
Catalepsy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Cannabinol (CBN) and Cannabidiol (CBD) were tested in several test procedures known to be altered by δ 9-tetrahydrocannabinol (THC) or crude cannabis preparations. They were inactive in doses up to 80 mg/kg in tests on animal motility, food and water intake, body temperature and catalepsy. In contrast, CBD enhanced the hexobarbitone “sleeping time” more pronounced than δ 9-THC whereas CBN increased the “sleeping time” only slightly. When administered in combination CBD prolonged all actions of THC, whereas CBN selectively blocked the effect of THC on hexobarbitone “sleeping time”. The enhancement by CBD is best explained by an inhibition of THC-metabolism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00429130
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