Electronic Resource
Springer
Clinical and experimental medicine
153 (1970), S. 237-245
ISSN:
1591-9528
Keywords:
Glucuronic acid cycle
;
aMPS
;
Diabetes mellitus
;
Diabetic vascular disease
;
Arterial wall
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The presence of all enzymatic steps of the glucuronic acid pathway could be demonstrated in arteries of various species.14C-D-glucose was converted into14C-D-glucuronic acid; 6-14C-D-glucuronic acid was decarboxylated to14CO2 and U-14C-D-glucuronic acid was transformed into14C-xylitol. NADP-L-xylulose oxidoreductase (E.C. 1.1.1.10) could be shown in tissue homogenate. Myoinositol was not converted into glucuronic acid in arteries. The rate of decarboxylation of glucuronic acid in various species was identical irrespective of the presence of ascorbic acid synthesis. The rate of decarboxylation of 6-14C-D-glucuronic acid and the rate of transformation of U-14C-D-glucose into14C-D-glucuronic acid was not elevated in alloxandiabetic animals and the activity of L-xylulose-oxidoreductase was unchanged in animals with experimental diabetes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02048757
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