ISSN:
1432-2072
Keywords:
Lithium
;
Thyroid
;
Iodine Release
;
Affective Disorder
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Thyroid iodine release measured by the double isotope method of Nicoloff was studied in patients with manic-depressive illness before, during and after treatment with lithium carbonate. The urinary 125I/131I isotope ratio was measured following administration of Na125I and 131I-thyroxine. In three of four subjects, lithium caused a transient decrease in diurnal variation and a temporary reduction in the normal increase of the 125I/131I ratio during the first week of therapy or after a lithium dose increase. In addition, in two of three subjects, a rebound increase in the isotope ratio occurred following cessation of lithium administration. These changes most likely represent a direct inhibitory effect of lithium on the thyroid iodine release process.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00437754
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