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  • 1970-1974  (5)
  • Sciatic nerve, rat  (4)
  • Osmotic stimulus  (1)
  • Neurohypophysis
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Material
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    A study of degeneration and regeneration in the divided rat sciatic nerve based on electron microscopy (1972)
    Springer
    Cell & tissue research 124 (1972), S. 103-130 
    Details
    ISSN: 1432-0878
    Keywords: Peripheral nerves ; Myelinated axons ; Regeneration ; Sciatic nerve, rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In the first six days after division myelinated axons in the proximal stump of rat sciatic nerves produce collateral and terminal sprouts. These are present as circumscribed “groups” which are positively distinguishable from clusters of non-myelinated axons. Two types of “groups” are identifiable, and their distribution in some of the nerve segments is analysed. Their evolution was followed in sequential nerve segments, the initial ‘tight’ structure becoming looser between 7 and 10 days, and myelinated axons appeared in them during this time. At this stage a complete basal lamina was present surrounding the entire “group”. Some of the cells in the “groups” did not have the characteristics of Schwann cells. Between 7 and 10 days after division alveolate vesicles and densely staining material in the cisternae of the rough surfaced endoplasmic reticulum were prominent in Schwann cells in the distal part of the proximal stump. It is thought that both types of “group” are developed from single myelinated axons and the name “regenerating unit” is proposed for both types. Their relationship to “clusters”, seen in the distal stump of regenerating peripheral nerves, and “onion bulbs”, present in some peripheral neuropathies, is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335457
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    A study of degeneration and regeneration in the divided rat sciatic nerve based on electron microscopy (1972)
    Springer
    Cell & tissue research 124 (1972), S. 165-203 
    Details
    ISSN: 1432-0878
    Keywords: Peripheral nerves ; Regeneration ; Sciatic nerve, rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Between seven days and six weeks after division the internal architecture of rat sciatic nerves is altered, their original mono- or di-fascicular configuration being replaced by a collection of small fascicles each surrounded by perineurium. This change, called by us ‘compartmentation’, has a minimum retrograde extent of 3.5 mm and is brought about by changes in Schwann cells and endoneurial fibroblasts, which undergo circumferential elongation to surround groups of axons and so come to resemble perineurial cells. Ultrastructural changes occur in these cells during compartmentation. There is a marked rise in the number of endoneurial fibroblasts in the distal segments of the proximal stump. The stimulus to the development of compartmentation is considered to be disturbance of the endoneurial environment following rupture of the perineurium. Changes in the structure and appearance of endoneurial cells suggest that metaplasia occurs between Schwann cells, endoneurial fibroblasts and perineurial cells, and it is concluded that these cell types in the endoneurium have a common origin from embryonic ectoderm. This suggests that the surgical treatment of peripheral nerve injuries should be primarily directed to the reconstitution of the endoneurial environment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335678
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    A study of degeneration and regeneration in the divided rat sciatic nerve based on electron microscopy (1972)
    Springer
    Cell & tissue research 124 (1972), S. 103-130 
    Details
    ISSN: 1432-0878
    Keywords: Peripheral nerves ; Myelinated axons ; Regeneration ; Sciatic nerve, rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In the first six days after division myelinated axons in the proximal stump of rat sciatic nerves produce collateral and terminal sprouts. These are present as circumscribed “groups” which are positively distinguishable from clusters of non-myelinated axons. Two types of “groups” are identifiable, and their distribution in some of the nerve segments is analysed. Their evolution was followed in sequential nerve segments, the initial ‘tight’ structure becoming looser between 7 and 10 days, and myelinated axons appeared in them during this time. At this stage a complete basal lamina was present surrounding the entire “group”. Some of the cells in the “groups” did not have the characteristics of Schwann cells. Between 7 and 10 days after division alveolate vesicles and densely staining material in the cisternae of the rough surfaced endoplasmic reticulum were prominent in Schwann cells in the distal part of the proximal stump. It is thought that both types of “group” are developed from single myelinated axons and the name “regenerating unit” is proposed for both types. Their relationship to “clusters”, seen in the distal stump of regenerating peripheral nerves, and “onion bulbs”, present in some peripheral neuropathies, is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00981944
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    A study of degeneration and regeneration in the divided rat sciatic nerve based on electron microscopy (1972)
    Springer
    Cell & tissue research 124 (1972), S. 131-164 
    Details
    ISSN: 1432-0878
    Keywords: Peripheral nerves ; Injuries ; Axons ; Sciatic nerve, rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Changes in the proximal stump of axons of divided rat sciatic nerves in the first 6 weeks after nerve section were studied, particularly in terms of alterations in the organelle content, axoplasmic ultrastructure and the diameter of the axons. A variety of organelle types were observed; quasi-membranous structures, multivesicular bodies, dense bodies, vesicles and tubules, dense cored vesicles and alveolate vesicles: their identification and the functional implications of their presence are discussed. Alterations in the ultrastructure of the “stained” elements of the axoplasm are described. Axons containing excess organelles were divided into classes, comprising myelinated axons; and “supergiant”, “giant” and “conventional” non-myelinated axons. Temporal changes in these axons are described. The characteristics of the various classes of apparently non-myelinated axon are considered in terms of their identification as regenerating terminal sprouts of myelinated axons, segmentally demyelinated axons, sections through abnormal nodes of Ranvier or merely non-myelinated axons. The structure of axons in “regenerating units” is described. Changes in the neurofilament microtubule ratio of small axons without excess organelles are demonstrated, and “spiralling” of neurofilaments in some myelinated and non-myelinated axons with normal axoplasmic ultrastructure is illustrated and discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335677
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    A quantitative study of the ultrastructural changes in the hypothalamo-neurohypophysial system during and after experimentally induced hypersecretion (1974)
    Springer
    Cell & tissue research 149 (1974), S. 525-535 
    Details
    ISSN: 1432-0878
    Keywords: Supraoptic and paraventricular nuclei ; Ultrastructure ; Osmotic stimulus ; Quantitative study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Substitution of a 2% solution of sodium chloride in place of drinking water for 3 days significantly increased both the size of neurosecretory neurones in the supraoptic and paraventricular nuclei of rats and the proportion of these cells which had dilated endoplasmic reticulum. There was an increase in the number of multivesicular bodies per mean cell profile and also an increase in the ratio of “dense” (immature) to “pale” (mature) neurosecretory granules within the perikarya, although the total numbers of granules were unchanged. If, after 3 days of saline-treatment, the rats were again allowed tap water to drink for 2 days, the proportion of cells showing dilated endoplasmic reticulum and the number of multivesicular bodies returned towards normal, but there was a significant increase in the number of large dense lysosomal bodies per cell profile and a relative increase in the proportion of “pale” (mature) neurosecretory granules. These changes suggest that the increased bio-synthetic activity resulting from saline-treatment subsides when the treatment is terminated. Furthermore, since neurohypophysial hormone stores have still not returned to normal in animals of the recovery group, they also imply the absence of an internal feedback system by which the level of neural lobe hormone stores might govern the synthetic activity of the neurosecretory cells. Both the increased synthesis, and the increased electrical activity which accompanies it, may be independent consequences of the depleting stimulus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223030
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    Paper (German National Licenses)
    Fulltext
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