ISSN:
1432-2013
Keywords:
Prostaglandins
;
Thermoregulation
;
Hypothalamic Neurotransmitters
;
Brain Prostaglandins
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary ProstaglandinsE 1,E 2,F 1α andF 2α injected into a lateral cerebral ventricle of the conscious sheep during exposure to various environmental conditions caused deep body temperature to rise. In a cool environment, faint shivering which was normally present became intensified and peripheral vasoconstriction became maximal. In a thermoneutral environment, shivering and vasoconstriction were elicited. In a warm environment, panting was markedly reduced and there was sometimes slight vasoconstriction. ProstaglandinsE 1 andE 2 were most effective,F 2α was slightly less, andF 1α considerably less effective. It was concluded that prostaglandins may be involved in transmission along brain neuronal pathways involved in the stimulation of heat production and increased peripheral vasomotor tone, and in the inhibition of heat loss mechanisms.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00587179
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