ISSN:
1432-1912
Keywords:
Trimethoprim
;
Rat Folic Acid Reductase
;
Pregnancy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The increased level of folic acid reductase activity in rats during the perinatal period is inhibited following the oral administration of 5 or 50 mg/kg Trimethoprim. When the enzyme activity was tested in vitro, the highest sensitivity to the antimetabolite was displayed by the liver reductase isolated from rats the 20th day of pregnancy, the lowest was observed in the foetal liver extract. It is proposed that the stimulated reductase activity during the pregnancy is caused by a newly synthesized, Trimethoprim-sensitive enzyme form. The results of the in vitro experiments could contribute to the suggested hypothesis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00500653
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