ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Condensation of a mixture of 25 mole per cent of 5′-O-p-methoxy-trityl-thymidine3′-[(β-cyanoethyl)phosphate] and 75 mole per cent of thymidine 3′-[(β-cyanoethyl)phosphate] in pyridine yielded a mixture of oligonucleotides, the largest being the pentanucleotide. It was demonstrated that longer chains are not obtained due to the formation of a C-pyridinium-thymidine nucleotide. For avoiding this undesired side reaction, the condensation was carried out using sym.-collidine as solvent. The analogous side reaction was not observed, longer chains of oligonucleotide were not obtained, however.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19720550611
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