ISSN:
1432-1424
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Summary The effect of a water-soluble carbodiimide has been used to study the nature of the presumed anionic part of the acetylcholine (ACh) receptor at the frog neuromuscular junction. The ACh sensitivity has been measured by the moving fluid electrode method and by recording end plate potentials with microelectrodes. The carbodiimide blocked ACh sensitivity without marked effect on the membrane resistance or potential difference. The conditions of reversibility of the block and the results obtained with phospholipids suggest that a carboxyl group is important in the combination of ACh with the receptor.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01869855
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