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  • 1970-1974  (9)
  • 1
    Electronic Resource
    Electronic Resource
    EFFECT OF INCREASED RAT BRAIN TRYPTOPHAN ON 5-HYDROXYTRYPTAMINE AND 5-HYDROXYINDOLYL ACETIC ACID IN THE HYPOTHALAMUS AND OTHER BRAIN REGIONS (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 22 (1974), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —Tryptophan was found at higher concentration in the rat hypothalamus than in other brain regions. This difference was explicable neither by regional differences in blood content nor by differences in tryptophan recovery from different weights of tissue. It was not due to interference by other known brain indoles. After food deprivation or tryptophan injection the tryptophan concentration rose in all regions. Total 5-hydroxyindole increases showed regional differences but relative changes were similar after both procedures. Increases in 5-hydroxytryptamine were clearest in midbrain + hippocampus. In general, 5-hydroxyindolylacetic acid increased more markedly than 5-hydroxytryptamine. The hypothalamus appeared refractory with negligible increases of both 5-hydroxyindoles upon either food deprivation or tryptophan administration even though hypothalamic tryptophan concentration rose considerably. Results are discussed in relation to other evidence suggesting special characteristics of 5-HT regulation in the hypothalamus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1974.tb04338.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    PLASMA AND BRAIN TRYPTOPHAN CHANGES IN EXPERIMENTAL ACUTE HEPATIC FAILURE (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 21 (1973), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An experimental model for acute hepatic failure in man was obtained in pigs by hepatic devascularization. After operation, liver function was grossly impaired, movements became inco-ordinated and coma ensued. Most animals died 5½–8½ h after operation. Plasma unesteritied fatty acid and free (but not total) tryptophan concentrations rose markedly after operation and correlated significantly with each other. Brain tryptophan concentration increased and correlated significantly with plasma free tryptophan concentration. Increased tryptophan was found in the four brain regions studied (hypothalamus, thalamus, caudate and cortex) and was associated with raised 5-hydroxytryptamine turnover as indicated by raised 5-hydroxyindolylacetic acid concentration. Results are discussed in relation to altered tryptophan metabolism in human hepatic coma and to investigations of the influence of plasma unesterified fatty acid and free tryptophan changes on brain tryptophan metabolism in the rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1973.tb04233.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    EFFECTS OF LESIONS AND DRUGS ON BRAIN TRYPTAMINE (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 23 (1974), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— The effects of various drugs and lesions on rat brain 5-hydroxytryptamine and tryptamine were determined. Monoamine oxidase inhibition caused a proportionately greater increase in tryptamine than in 5-hydroxytryptamine, reserpine depleted 5-hydroxytryptamine but had no effect on tryptamine while p-chlorophenylalanine lowered 5-hydroxytryptamine but increased tryptamine. α-Methyl-p-tyrosine reduced striatal dopamine with no effect on either 5-hydroxytryptamine or tryptamine. Increasing brain tryptophan by amphetamine administration. 24 h food deprivation or giving L-tryptophan did not increase brain tryptamine. However a high dose of L-tryptophan (100 or 200mg/kg) together with a monoamine oxidase inhibitor caused a proportionately much greater increase in tryptamine than in 5-hydroxytryptamine. Raphe lesions reduced 5-hydroxytryptamine by 64 per cent and tryptamine by only 29 per cent while intraventricular 6-hydroxydopamine lowered striatal dopamine (56 per cent), had no effect on 5-hydroxytryptamine but reduced tryptamine by 24 per cent, suggesting that tryptamine can be formed in both 5-HT and catecholaminergic neurones.The results are discussed in relation to the formation, distribution, storage and possible transmitter function of tryptamine in rat brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1974.tb12214.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    EFFECTS OF IMMOBILIZATION AND FOOD DEPRIVATION ON RAT BRAIN TRYPTOPHAN METABOLISM (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 19 (1972), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Withdrawal of food or immobilization both led to changes in rat brain tryptophan metabolism. Brain tryptophan and 5-hydroxyindolylacetic acid concentrations both increased while changes in 5-hydroxytryptamine were much smaller. Changes were greater upon withdrawal of food. The brain tryptophan change did not appear merely to reflect an overall increase of brain amino acid concentrations, brain tyrosine concentration being only slightly increased by food withdrawal and significantly decreased upon immobilization. Plasma tryptophan did not increase. The changes in brain indole metabolism were not abolished by adrenalectomy. Results are discussed in relation to the regulation of brain serotonin metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1972.tb01486.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of electroconvulsive therapy on plasma unesterified fatty acid and free tryptophan concentrations in man (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 22 (1974), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1974.tb06901.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of food deprivation and immobilization on tryptophan and other amino acids in rat brain (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 20 (1973), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1973.tb12123.x
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    The Effect of Fatty Acids on the Binding of Tryptophan to Plasma Protein (1973)
    [s.l.] : Nature Publishing Group
    Nature 242 (1973), S. 198-200 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Food deprivation3'4 or immobilization stress4 both lead to increased brain tryptophan and increased turnover of brain 5HT as indicated by raised concentrations of its metabolite 5-hydroxyindolylacetic acid. The increase of brain tryptophan is not simply due to increased plasma tryptophan as these ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/242198a0
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Free Tryptophan in Plasma and Brain Tryptophan Metabolism (1972)
    [s.l.] : Nature Publishing Group
    Nature 239 (1972), S. 452-453 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Although brain tryptophan is presumably derived from plasma, the brain and plasma concentrations of this amino-acid are not significantly correlated. Plasma tryptophan concentration is unaltered when brain tryptophan increases upon food deprivation or immobilization4'5. However, only a small ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/239452a0
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Fortuitous Correlations? (1974)
    [s.l.] : Nature Publishing Group
    Nature 247 (1974), S. 82-82 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR,–The article 'What's in a Name?' (Nature, 246, 385; 1973) pointed out a number of significant correlations but ignored the rich contributions made by brain research workers to this field1-4. Yours faithfully, G. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/247082d0
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    Paper (German National Licenses)
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