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  • 1970-1974  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Fate of the analgesic and anti-inflammatory drug K 4277 after oral administration to man (1973)
    Springer
    European journal of clinical pharmacology 6 (1973), S. 256-260 
    Details
    ISSN: 1432-1041
    Keywords: K 4277 ; anti-inflammatory agents ; metabolism ; man ; oral administration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The fate of the new analgesic and anti-inflammatory agent α-[4-(1-oxo-2-iso-indolinyl)-phenyl]-propionic acid (compound K 4277) in healthy volunteers has been investigated by a radio-isotope method and gas-liquid chromatography. After oral administration, the drug was absorbed rapidly and completely and occurred in plasma mainly as unchanged compound bound extensively to plasma proteins. Its disappearance from plasma followed at least a bi-exponential function and was almost complete in 24 to 48 h. Most of the drug is excreted in urine as a glucuronide and a lesser amount as the unchanged compound. There were only negligible amounts of other metabolites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00644742
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of two new beta-blocking drugs on heart rate and blood pressure during passive tilting in man (1971)
    Springer
    European journal of clinical pharmacology 4 (1971), S. 12-17 
    Details
    ISSN: 1432-1041
    Keywords: Beta-blockers ; tilting ; heart rate ; blood pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Inhibition of heart rate increase during passive tilting was used as a test for rapid screening of two new benzo-bicyclic beta-blocking agents in man. Eight healthy volunteers were treated with single oral doses of the new drugs (K 4423, K 4540) and two oral doses of propranolol as reference drug. The test provided a useful means of assessing the relative potencies of these new drugs in man. The study showed that beta-blockers, in doses large enough substantially to inhibit the increase in heart rate during passive tilting, may decrease systolic and to a lesser extent diastolic blood pressure in normotensive subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00568892
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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