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  • 1
    Electronic Resource
    Electronic Resource
    Althesin in Africa (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 28 (1973), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1973.tb00559.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Anticonvulsant effects of cannabinoids in mice: Drug interactions within cannabinoids and cannabinoid interactions with phenytoin (1974)
    Springer
    Psychopharmacology 37 (1974), S. 255-264 
    Details
    ISSN: 1432-2072
    Keywords: δ 9-Tetrahydrocannabinol ; Cannabidiol ; Cannabinol ; Phenytoin ; Phenobarbitone ; Anticonvulsant ; Drug-Interactions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The anticonvulsant activity of orally administered δ 9-tetrahydrocannabinol (δ 9-THC), δ 8-THC, cannabidiol (CBD) and cannabinol (CBN) was tested in mice utilizing electroshock and chemoshock methods. In doses tested δ 9-THC afforded no protection to mice from chemoshock seizures and was effective against electroshock only in high doses (160–200 mg/kg). CBD and CBN (150–200 mg/kg) were without effect in both tests. An interaction between cannbinoids was apparent when all three were administered simultaneously (each at 50 mg/kg) because this combination produced a significant reduction in the duration of the hind-limb extensor phase of the electroshock seizures. The administration of δ 9-THC significantly potentiated the anticonvulsant effectiveness of phenytoin against electroshock seizures and this effect was further potentiated by the concurrent administration of CBD. Whilst the potentiation of phenytoin by δ 9-THC (50 mg/kg) was of the order of 1.5 times, the combination of δ-9THC and CBD (each 50 mg/kg) produced a four-fold potentiation. Neither within-cannabinoid interaction nor cannabinoid potentiation of phenobarbitone effectiveness could be demonstrated in chemoshock tests. The mechanism of the cannabinoid facilitation of phenytoin is unknown but it possibly involves activity at central nervous system level rather than being a metabolic interaction. This drug interaction may have potential clinical significance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421539
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of withdrawal from cannabis on pentylenetetrazol convulsive threshold in mice (1974)
    Springer
    Psychopharmacology 40 (1974), S. 129-135 
    Details
    ISSN: 1432-2072
    Keywords: Withdrawal ; Cannabis ; Convulsive Threshold
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Groups of mice were dosed with ethanol (2.5 and 5% w/v in drinking water) or cannabis extract (equivalent to 10, 20, 40 and 80 mg δ 9-THC/kg) orally, for 11, 13 and 28 days. The threshold to convulsions produced by the constant intravenous infusion of pentylenetetrazol was determined at various intervals after drug administration had ceased. The convulsive thresholds of mice tested 6 hrs after withdrawal from both doses of ethanol were significantly lower than controls. There was no significant difference from controls in the convulsive threshold of mice which had received cannabis extract at any of the doses employed when tested 6 hrs, 16 hrs, 1, 3 or 6 days after medication had been withdrawn. These findings support the contention that there is no abstinence syndrome evident following the withdrawal of cannabinoids after prolonged administration to mice and serve again to draw a distinction between cannabis and ethanol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421362
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    Paper (German National Licenses)
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