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  • 1
    Electronic Resource
    Electronic Resource
    Motor disturbance induced by tremorine and oxotremorine (1970)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 267 (1970), S. 80-98 
    Details
    ISSN: 1432-1912
    Keywords: Tremor ; Rigidity ; α andγ Motor Activity ; Tremorine ; Oxotremorine ; Antitremor Agents ; Antiparkinson Agents ; Tremor ; Rigor -α undγ-motorische Aktivität ; Tremorin ; Oxotremorin ; Antitremorstoffe ; Antiparkinsonstoffe
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The action of tremorine and oxotremorine on spinal motor activity was studied in the rat. Both tremorogenio agents increased a reflex activity and spontaneousγ activity. The increase in spontaneousγ activity consisted of rhythmic bursts ofγ discharges. The increase in a reflex activity was accompanied by rigidity, which manifested itself by the appearance of tonic muscle activity. Tremorine and oxotremorine-induced tremor was depressed by the antitremor agents metixene and Kr 339, the antiparkinson drugs atropine and biperiden, and the adrenergicβ receptor blocking agents propranolol and pronethalol. The adrenergicα. receptor blocking agents azapetine, dihydroergotamine, haloperidol, phenoxybenzamine and phentolamine failed to inhibit tremor activity. Chlorpromazine, however, as well as procaine, verapamil and DOPA, diminished the intensity of tremor activity without blocking the generation of tremor bursts. Drugs which depressed tremor activity also antagonized the effect of oxotremorine onα andβ motor activity, whereas the drugs, which only diminished tremor intensity, depressed the increasedα reflex discharge without reducing spontaneousγ activity. Rigidity disappeared whenα reflex discharge was normalized. It is concluded that experimental parkinsonlike rigidity may be interpreted in terms of a disturbed balance between monoaminergic and cholinergic mechanisms in the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00997117
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  • 2
    Electronic Resource
    Electronic Resource
    Depression by amantadine of tremor induced by reserpine and oxotremorine in the rat (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 280 (1973), S. 141-152 
    Details
    ISSN: 1432-1912
    Keywords: Tremor Activity ; Alpha and Gamma Motoneurones ; Reserpine ; Oxotremorine ; Amantadine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Reserpine and oxotremorine tremor as well as the effect of amantadine on the tremor activity produced by both drugs were studied in rats with respect to changes in alpha and gamma motor activity. The tremor activity elicited by reserpine (10 mg/kg i.v.) is maintained by the alpha motoneurones, whereas the tremor activity developing during an infusion of oxotremorine (40 μg/kg·min) is triggered by the gamma motoneurones. Amantadine (50 mg/kg i.v.), which itself elicited tremor activity, abolished the tremor produced by oxotremorine. The tremor activity resulting from an administration of reserpine was inhibited by amantadine in rats with their dorsal roots cut; in rats with intact dorsal roots, tremor activity persisted after reserpine and amantadine. It is concluded that the tremor resulting from reserpine and oxotremorine is brought about by an action of the two drugs on different structures of the central nervous system. The anti-tremor effect of amantadine is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499175
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The site of action of the optical isomers of 1-methyl-5-phenyl-5-propyl barbituric acid (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 282 (1974), S. 367-377 
    Details
    ISSN: 1432-1912
    Keywords: Spinal Reflexes ; Neuronal Membranes ; Potentials ; Optical Isomers ; Barbituric Acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of the optical isomers of 1-methyl-5-phenyl-5-propyl barbituric acid (MPPB) on spinal reflexes and on single motoneurones was studied in spinal animals after intravenous administration. The amplitudes of mono- and polysynaptic reflexes in the rat were reduced by (−)-MPPB (50 mg/kg) and increased by (+)-MPPB (50 mg/kg). (−)-MPPB (25 mg/kg) increased the membrane resistance and the firing level of cat motoneurones and reduced the amplitude of monosynaptic excitatory postsynaptic potentials. (+)-MPPB (25 mg/kg) lowered the membrane resistance and the firing level of the motoneurones and increased the monosynaptic excitatory postsynaptic potentials. Both isomers did not influence significantly the resting potential and the action potentials elicited by antidromic stimulation. It is concluded that the two isomers of MPPB in the doses employed act on post- and presynaptic sites and, moreover, produce their opposite effects (depression or excitation, respectively) by an action on the same neuronal membranes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500985
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    Paper (German National Licenses)
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