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  • 1
    Electronic Resource
    Electronic Resource
    SOME NEUROCHEMICAL ASPECTS OF PENTAMETHYL-ENETETRAZOLE CONVULSIVE ACTIVITY IN RAT BRAIN (1970)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 17 (1970), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— The concentrations of several metabolites, including glucose, glycogen, hexose phosphates, adenine nucleotides, amino acids and some tricarboxylic cycle intermediates were estimated in cerebral tissue of rats killed at various stages of pentamethylenetetrazole convulsions. Prior to and during the seizure there was an increase in glycolytic flux and depletion of energy reserves. An accumulation of alanine concomitant with a decreased citrate level observed before the convulsion indicated that a possible interference of pyruvate entry into the tricarboxylic cycle had occurred. At the tonic extensor phase of the seizure and during post-convulsive sedation a small but significant rise in GABA and an attempt to restore some of the labile constituents to more normal values was apparent. The significance of these results in relation to cerebral metabolic control and possible mechanisms of initiation and arrest of the seizure is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1970.tb00542.x
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  • 2
    Electronic Resource
    Electronic Resource
    Studies on interactions involving antidepressive and other drugs with tetrabenazine and noradnamine on locomotor activity in mice, including details of the experimental design and statistical analysis (1970)
    Springer
    Psychopharmacology 18 (1970), S. 288-299 
    Details
    ISSN: 1432-2072
    Keywords: Noradnamine ; Tetrabenazine ; Locomotor Activity ; Drug Interactions ; Statistical Analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A method for the measurement of drug interactions on locomotor activity in mice has been described. The experiments were designed on a factorial basis and the data obtained were subjected to variance analysis. Using the principles described, the effects of various drugs on the hypoactivity induced by noradnamine or tetrabenazine were studied. Twenty potential drug interactions were examined, but only seven of these exhibited statistically significant interaction. Tetrabenazine hypoactivity was antagonised by nortriptyline, amitriptyline, nialamide and noradnamine. The latter also potentiated the effect of a low dose of tetrabenazine. Hypoactivity induced by noradnamine was antagonised by amitriptyline and nortriptyline, potentiated by atropine but unaffected by nialamide. The significance of these findings is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412674
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    Paper (German National Licenses)
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