ISSN:
0030-493X
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The electron-impact induced fragmentation of staphylomycin S (I) and related cyclodepsipeptides (II to V) is mainly initiated by elimination of an azomethin molecule (R—CH=N—R′), i.e. 1,2-dehydro-4-oxopiperidine for I and II, 1,2-dehydro-4-hydroxy-piperidine for III and IV, and an unknown hydroxy-1,2-dehydro-4-oxopiperidine for VI. Cyclic imino acids, e.g. a pipecolic acid derivative for I to IV and 4-hydroxyproline for etamycin (IX) preferentially trigger this reaction. Clearcut evidence for the amino acid sequence is given by the mass spectra of the linear peptides obtained from I, V and IX by alkaline hydrolysis of the lactone function and esterification of the carboxy group.
Additional Material:
9 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/oms.1210060205
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