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  • 1
    Electronic Resource
    Electronic Resource
    Glutathione-oxytocin transhydrogenase of human placental origin with specificity towards neurohypophysial hormones (1974)
    [s.l.] : Nature Publishing Group
    Nature 251 (1974), S. 237-239 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Of the enzyme systems capable of destroying oxytocin, those associated with pregnancy have been the most extensively studied9. Fekete10 first demonstrated that pregnancy serum inactivated the oxytocic activity found in the posterior pitiutary lobe and it was later shown11 that the inactivation of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/251237a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrastructure of the rat posterior pituitary gland and evidence of hormone release by exocytosis as revealed by freeze-fracturing (1973)
    Springer
    Cell & tissue research 143 (1973), S. 465-484 
    Details
    ISSN: 1432-0878
    Keywords: Neurohypophysis ; Membranes ; Exocytosis ; Ultrastructure ; Freeze-fracturing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Posterior pituitary glands from normal rats, and rats which had been deprived of water for varying periods, were examined by the freeze-fracture method. This technique reveals large areas of the nerve cell membrane. Images consistent with exocytosis as the mechanism of release of the neurohypophysial hormones were observed. These modifications were most numerous after the rat had been starved of water for 2 days. In normal rats, the large number of neurosecretory granules within the nerve fibres caused a bulging of the nerve cell membrane. The “bulges” disappeared 2 days after removal of drinking water. Regions of the membrane displaying “bulges” were characterised by the absence of the typical membrane-associated particles. It is postulated that the close proximity of the neurosecretory granules to the nerve cell membrane may result in rapid fusion of the neurosecretory granules on stimulation of the gland. The change in properties of the nerve cell membrane overlying the neurosecretory granules, as suggested by the loss of membrane-associated particles, may represent a change in the structure of the membrane to a form which is more favourable for fusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00306766
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Localization of neurophysin in the neurosecretory elements of the hypothalamus and neurohypophysis of the normal and osmotically stimulated guinea-pig as demonstrated by immunofluorescence histochemical techniques (1973)
    Springer
    Cell & tissue research 145 (1973), S. 39-55 
    Details
    ISSN: 1432-0878
    Keywords: Magnocellular hypothalamic nuclei ; Accessory structures ; Neurosecretory pathways ; Neurophysin-like material ; Immunofluorescence histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Antisera to porcine neurophysin-II and ovine neurophysin-III were used to localize neurophysin-like material in the hypothalamus and neurohypophysis of guinea-pigs with an immunofluorescence technique. Although the guinea-pig appears to have only one major neurophysin it was found to be localized in both of the bilateral magnocellular nuclei. Neurophysin-like material was also present in extreme rostral portions of the hypothalamus, in cells lying between the third ventricle and the supraoptic nucleus and in a cluster of cells dorsomedial to the fornix. Immunofluorescence was observed in neurosecretory fibres that followed pathways previously characterized with classical histological stains for “neurosecretory material”. The immunofluorescence in the hypothalamic elements of a normal guinea-pig was not greatly different from that in fluorescent structures present in an animal that had been severely dehydrated. In contrast, there was a marked depletion of neurophysin from the posterior pituitary gland of the dehydrated guinea-pig. The lack of graded fluorescence in the hypothalamus of the dehydrated animal is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307188
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Neurophysin and the neurosecretory fibres of the sheep infundibulum (1973)
    Springer
    Cell & tissue research 145 (1973), S. 471-478 
    Details
    ISSN: 1432-0878
    Keywords: Neurophysins (sheep) ; Neurosecretory pathways ; Proximal and distal neurohypophysis ; Infundibulum ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A cross-species reactive antiserum was used to study the cellular localization of neurophysin in the sheep hypothalamus and neurohypophysis. The immunofluorescent technique was used to follow the neurosecretory fibres emanating from the magnocellular nuclei to the lower infundibular stem. It was confirmed that neurophysin was present in both the internal and external zone of the infundibulum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00306719
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Immunohistochemical demonstration of a CRF-associated neurophysin in the external zone of the rat median eminence (1974)
    Springer
    Cell & tissue research 152 (1974), S. 411-421 
    Details
    ISSN: 1432-0878
    Keywords: Median eminence (rat) ; External zone ; Adrenalectomy ; CRF-neurophysin ; Immunoperoxidase histochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In picric acid-formalin fixed, paraplast embedded median eminence sections from normal and bilaterally adrenalectomized rats, the amount of “Gomori-positive” neurosecretory material and the amount of protein, cross reacting against a porcine neurophysin-II antiserum were determined. In normal rats, “Gomori-positive” substances and neurophysin were confined to the internal zone of the median eminence. After adrenalectomy, however, “Gomori-positive” granules and a neurophysin-like protein also became apparent in the external zone. Their amount increases, if the animals are treated with DOCA from the 15th to the 21st day after the operation. The distribution of the neurophysin-like protein in the external zone is similar to that of the “Gomori-positive” granules. Since the granules are regarded as a morphological correlate of the corticotropin-releasing factor (CRF) it is assumed, that the protein, appearing in the external zone after adrenalectomy and cross-reacting against the neurophysin antiserum is a CRF-associated neurophysin. For this substance the name “CRF-neurophysin” is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218928
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  • 6
    Electronic Resource
    Electronic Resource
    Neurosecretion in the external and internal zone of the median eminence of the cat and dog (1974)
    Springer
    Cell & tissue research 155 (1974), S. 201-210 
    Details
    ISSN: 1432-0878
    Keywords: External median eminence (Cat, dog) ; Neurosecretory material ; CRF ; Neurophysin ; Immunoperoxidase histochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The immunoglobulin-enzyme bridge technique, in association with rabbit antiporcine neurophysin-II has been applied to the median eminence of the dog and cat in order to study the distribution of neurophysin-like antigens throughout this area of the brain and correlate the findings with the corresponding distribution of neurosecretory material (NSM) as revealed by the crotonaldehyde fuchsin stain. Neurophysin and NSM were both present in the hypothalamo-supraoptico-neurohypophysial system—the pathway taken by oxytocin, vasopressin and neurophysin from the hypothalamus to the posterior pituitary lobe. Whereas the tuberoinfundibular tract of the median eminence was almost devoid of NSM, the presence of neurophysin-like material was clearly evident using immunoperoxidase histochemistry. The significance of a protein in the external median eminence possessing determinants cross-reactive against anti-neurophysin serum is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221354
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  • 7
    Electronic Resource
    Electronic Resource
    Demonstration of neurophysin in the hypothalamo-neurohypophysial system of the normal and dehydrated rat by the use of cross-species reactive anti-neurophysins (1972)
    Springer
    Cell & tissue research 131 (1972), S. 149-170 
    Details
    ISSN: 1432-0878
    Keywords: Neurophysins ; Rat neurohypophysis ; Supraoptic and paraventricular nuclei ; Immunohistology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Antiserum raised against porcine neurophysin-II and ovine neurophysin-III has been shown to cross react with the three neurophysins of the rat. The antisera were used in the immunohistological demonstration of neurophysin in the posterior pituitary gland and the hypothalamic nuclei of a normal rat and a rat subjected to varying degrees of osmotic stress. Depletion of neurosecretory material from the neural lobe of the stimulated rat is also accompanied by a concomitant reduction in the neurophysin and vasopressin content of the gland. Neurophysin is present in the cytoplasm of both the supraoptic and paraventricular nuclei.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00306924
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