ISSN:
1432-2072
Keywords:
Nalorphine
;
Cyclazocine
;
Naloxone
;
Cocaine
;
Codeine
;
Pentazocine
;
Propiramfumarate
;
Negative Reinforcing Properties
;
Self-Administration Experiments
;
Rhesus Monkey
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Rhesus monkeys were trained to press a lever to extinguish a light associated with a drug infusion scheduled to occur 30 sec after the onset of the light. Each response during the light period terminated the light for a 1-min time-out period (avoidance); a response during the infusion terminated the infusion (escape). Under these conditions the monkeys tolerated a high number of saline infusions. Saline was replaced by different unit doses of nalorphine, cyclazocine, naloxone, cocaine, codeine, pentazocine and propiramfumarate each for six successive daily 2-h sessions. Infusions of nalorphine (unit doses from 500 to 10 mcg/kg/infusion) and cyclazocine (10 to 2.5 mcg/kg/infusion) generated and maintained avoidance/escape behavior, while infusions of naloxone (100 to 5 mcg/kg/infusion), cocaine, codeine, pentazocine and propiramfumarate (all 50 mcg/kg/infusion) were tolerated by the subjects. The results show that in rhesus monkeys with no drug experience prior to the experiment the morphine-antagonists nalorphine and cyclazocine but not naloxone have negative reinforcing properties.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00423059
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