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  • 1
    Electronic Resource
    Electronic Resource
    Trial of an anti-anxiety compound-Doxepin (Sinequan) (1969)
    Springer
    Psychopharmacology 15 (1969), S. 134-143 
    Details
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Anti-Anxiety ; Controlled Trial ; Doxepin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Six patients with persistent anxiety symptoms were used in a preliminary assessment of a new anti-anxiety compound-Doxepin (Sinequan) with placebo. The factorial design is discussed as a potentially useful way of conducting a first-stage test of anti-anxiety compounds. Analysis of the results showed that Doxepin at 25 mg t.d.s. and 50 mg t.d.s. was associated with improvement in the patient's self ratings of anxiety symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00407046
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Antagonism by antimuscarinic and ganglion-blocking drugs of some of the behavioural effects of nicotine (1969)
    Springer
    Psychopharmacology 15 (1969), S. 341-350 
    Details
    ISSN: 1432-2072
    Keywords: Nicotine ; Antimuscarinic Drugs ; Ganglion-Blocking Drugs ; Operant Conditioning ; Psychopharmacology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of nicotine on bar-pressing behaviour in the rat are blocked by mecamylamine. The depressant phase of the effect is blocked by atropine, supporting the conclusion that this depression is mediated by released acetylcholine. The quaternary compounds chlorisondamine and atropine methylnitrate also antagonise the behavioural effects of nicotine but the doses required for this are far in excess of those which are effective peripherally, suggesting that the sites of interaction are central.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403709
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    An hallucinogenic amphetamine analog (DOM) in man (1969)
    Springer
    Psychopharmacology 14 (1969), S. 62-73 
    Details
    ISSN: 1432-2072
    Keywords: Amphetamine ; Hallucinogens ; Drug Addiction ; Psychopharmacology ; Phenylethylamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The amphetamine analog, 2,5-dimethoxy-4-methylamphetamine (DOM), was studied in 18 volunteer subjects given single doses ranging from 2 to 14 mg. The former was a threshold dose, with definite psychotomimetic effects being evident from doses over 5 mg. The clinical syndrome greatly resembled that of the LSD-mescaline-psilocybin series of drugs, including its time-course. Somewhat more sedation was produced by DOM than would have been expected from the others, despite concomitant evidence of peripheral sympathetic stimulation. Just as with the other drugs, DOM increased plasma free fatty acids, decreased phosphorus and creatinine clearance, decreased circulating eosinophils and had little effect on catecholamine excretion. Performance of psychometric tests was impaired. Chlorpromazine treatment concurrently was found to attenuate the reaction. Tolerance rapidly developed when the drug was used chronically by patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401535
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  • 4
    Electronic Resource
    Electronic Resource
    Sample selection by diagnosis in clinical drug evaluations (1968)
    Springer
    Psychopharmacology 13 (1968), S. 118-128 
    Details
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Diagnosis ; Sampling Studies ; Statistics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Theoretical models for sample selection by diagnosis using one, one-out-of-two, two, two-out-of-three, and three concurring opinions are illustrated. These models are then applied to two categories, schizophrenia and depressive disorders, for an actual sample of patients diagnosed by multiple observers. The conclusion is reached that sample selection by a single opinion is not sufficiently reliable for research studies. The choice of alternative methods of selection depends on the needs of a particular study. Samples chosen on the basis of two-out-of-three concurring opinions provide the least total error. When erroneous inclusions are particularly undesirable, higher degrees of consensus—e.g. agreeing pairs or triplets—are necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404809
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  • 5
    Electronic Resource
    Electronic Resource
    Influencing the human indoleamine metabolism by means of a chlorinated amphetamine derivative with antidepressive action (p-Chloro-N-Methylamphetamine) (1968)
    Springer
    Psychopharmacology 13 (1968), S. 145-160 
    Details
    ISSN: 1432-2072
    Keywords: Indoleamine Metabolism ; Psychopharmacology ; Antidepressive Drugs ; Amphetamine Derivatives (Chlorinated) ; Depression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary CMA (p-chloro-N-methylamphetamine) lowers the cerebral 5-HT concentration in test animals but has virtually no effect on the catecholamine concentrations. Moreover, this compound was found to behave in depressive patients like an antidepressive drug, not like a central stimulant of the amphetmine type. The study described was conducted in order to establish whether CMA influences the overall metabolism of indoleamines in man. Such an influence was clearly demonstrable. Our findings are consistent with the hypothesis that CMA releases 5-HT from its depots. It has not been explained why a considerable proportion of the released 5-HT is excreted unchanged and why the increase in 5-HIAA excretion is so small: the overall activity of MAO was found not to be inhibited. No indications of abnormal 5-HT degradation were found at this time. Patients with vital depressions who improved on CMA medication showed a lower 5-HIAA excretion before treatment than did patients who were refractory to CMA treatment. This is consistent with earlier observations. The possible cause of this phenomenon is discussed. Among the various possibilities considered, an abnormal 5-HT metabolism is regarded as the most plausible. Pertinent investigations are being continued.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404812
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  • 6
    Electronic Resource
    Electronic Resource
    Alteration of the behavioral effects of amphetamine by agents which modify cholinergic function (1969)
    Springer
    Psychopharmacology 14 (1969), S. 142-149 
    Details
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Amphetamine ; Cholinergics ; Drug Interactions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Amphetamine was administered to a group of rats trained on a nondiscriminated avoidance procedure. An intraperitoneal dose of 2.0 mg/kg caused about a 75% increase in response rate for the three-hour session. Doses of atropine, Tremorine, eserine, and 4-(1-naphthylvinyl)-pyridine (NVP), an inhibitor of the enzyme choline acetylase, which were ineffective in themselves, markedly affected the increase in rate observed after amphetamine. The quarternary amine of NVP was without effect on the amphetamine response. Those agents that decreased cholinergic function, either by blocking the effect of acetylcholine or by preventing its synthesis, augmented the stimulating effect of amphetamine. Cholinergic stimulants, on the other hand, significantly antagonized the behavioral effects of amphetamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403687
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of DDT or Parathion on condition avoidance response of offspring from DDT or Parathion treated mothers (1968)
    Springer
    Psychopharmacology 12 (1968), S. 424-427 
    Details
    ISSN: 1432-2072
    Keywords: Central Nervous System ; Psychopharmacology ; DDT ; Parathion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The offspring of female mice treated with 2.5 mg/kg DDT during the second or third trimester of pregnancy showed a delayed acquisition of the conditioned avoidance response. If DDT was given in the first trimester, or if 3 mg/kg of Parathion was given during the pregnancy, no effect on the conditioned avoidance response of the off-spring was seen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401347
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  • 8
    Electronic Resource
    Electronic Resource
    Lack of cross-tolerance in rats among (−) Δ9-trans-tetrahydrocannabinol (Δ9-THC), cannabis extract, mescaline and lysergic acid diethylamide (LSD-25) (1968)
    Springer
    Psychopharmacology 13 (1968), S. 332-340 
    Details
    ISSN: 1432-2072
    Keywords: Cannabis ; Lysergic Acid Diethylamide ; Mescaline ; Hallucinogens ; Psychopharmacology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using climbing rope and bar-pressing behavior methods, rats were rendered tolerant to Δ 9-THC, cannabis extract, mescaline and LSD-25. Cross-tolerance experiments showed that rats refractory to Δ 9-THC and cannabis extract were still sensitive to mescaline and LSD-25, and vice-versa. These results suggest that, in spite of the similarity of the clinical symptoms produced in man by the 3 drugs, Δ 9-THC may have its psychotomimetic effects produced by different mechanisms from those of LSD-25 and mescaline.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414344
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  • 9
    Electronic Resource
    Electronic Resource
    Dimensions of the LSD, methylphenidate and chlordiazepoxide experiences (1969)
    Springer
    Psychopharmacology 14 (1969), S. 1-11 
    Details
    ISSN: 1432-2072
    Keywords: Lysergic Acid Diethylamide or LSD ; Methylphenidate or Ritalin ; Chlordiazepoxide or Librium ; Psychopharmacology ; Alcoholism and Drug Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Through the retrospective use of the 156 item DWM Card Sort, the experiences from a single intravenous dose of 200 mcg of LSD, 75 mg of methylphenidate (Ritalin) and 75 mg of chlordiazepoxide (Librium) were compared in a population of 99 chronic male alcoholics treated in an “LSD setting” in a double-blind study. Surprisingly, 96 of the 156 items proved significantly different among the 3 groups. LSD was unique in producing Sensory and Perceptual Distortions (including Hallucinations or Illusions), and Mystical, Religious or Paranormal Sensations. However, contrary to expectation, LSD did not uniquely produce the traditional “therapeutic” experience, but appeared to be surpassed in that area by methylphenidate. Both drugs also produced some anxiety, while chlordiazepoxide produced relaxation, and enhanced music appreciation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401528
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Locomotor activity and anorexogenic action (1969)
    Springer
    Psychopharmacology 14 (1969), S. 248-254 
    Details
    ISSN: 1432-2072
    Keywords: Amphetamine ; Appetite Depressants ; Psychopharmacology ; Sympathomimetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A method is described with which it is possible to measure locomotor activity and food intake simultaneously in the same rat or other small animal. From a study of a number of psychomotorstimulant drugs and anorectic agents it may be concluded that locomotorstimulation and appetite-suppression are two different effects that may or may not characterize the same drug. Methamphetamine and phenmetrazine are stimulants in doses that do not inhibit food intake. Amphepramon reduced food intake in low doses but acts as a stimulant in higher doses. Chlorphemternine and phenfluramine are anorectic agents that are not stimulants, even in high doses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404223
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