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  • 1
    ISSN: 1432-2013
    Keywords: Ventilation-Perfusion Ratio ; Diffusing Capacity-Perfusion Ratio ; Inhomogeneous Lung Function ; Alveolar Gas Dilution Method ; Alveolar-Arterial Tension Differences ; Ventilations-Perfusions-Verhältnis ; Diffusionskapazitäts-Perfusions-Verhältnis ; Inhomogene Lungenfunktion ; Alveoläre Einmischung ; Alveolär-arterielle Druckdifferenzen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird die theoretische Begründung für ein Untersuchungsverfahren gegeben, das gleichzeitig die Inhomogenitäten des Ventilations-Perfusions-Verhältnisses $$\dot V_A /\dot Q$$ sowie des Diffusionskapazitäts-Perfusions-Verhältnisses $$D_L /\dot Q$$ in der menschlichen Lunge zu bestimmen erlaubt. Dazu müssen drei inspiratorisch angebotene Gase, die sich in ihren Diffusionseigenschaften unterscheiden, z.B. CO2, O2 und He, plötzlich in ihren Konzentrationen verändert und die nachfolgenden alveolären Einmischvorgänge fortlaufend verfolgt werden. Die Lösungen der Differentialgleichungen für die drei Einmischprozesse zeigen, daß deren Zeitkonstanten in unterschiedlicher Weise von der alveolären Ventilation $$\dot V_A $$ , der Lungendurchblutung $$\dot Q$$ und der DiffusionskapazitätD L abhängen. Aus den Zeitkonstanten lassen sich daher die funktionellen Verteilungen von $$\dot V_A ,\dot Q$$ undD L berechnen. Diese Verteilungskurven bilden dann die Grundlage für die Bestimmung der diagnostisch wichtigen Anteile der alveolär-arteriellen DruckdifferenzAαD für Sauerstoff und Kohlendioxyd. Auf diese Weise findet man dieAαD Distr. 1, die auf Verteilungsungleichmäßigkeiten von $$\dot V_A /\dot Q$$ zurückzuführen ist, ferner dieAαD Distr. 2, die von der Größe und Verteilung von $$D_L /\dot Q$$ abhängt, und schließlich die durch das Ausmaß der extrapulmonalen Kurzschlußdurchblutung bestimmteAαD sh .
    Notes: Summary The theoretical basis is given for an examination method, which, at the same time, enables the inhomogeneities of the ventilation-perfusion ratio, $$\dot V_A /\dot Q$$ , as well as the diffusing capacity-perfusion ratio, $$D_L /\dot Q$$ , in the human lung to be determined. In addition, the concentrations of three inspiratory gases with different diffusing characteristics, e.g. CO2, O2, and He, must be suddenly varied, and the subsequent alveolar mixing processes followed. The solutions of the differential equations for the three mixing processes show that their time constants depend to a varying degree on the alveolar ventilation, $$\dot V_A $$ , the lung perfusion, $$\dot Q$$ , and the diffusing capacity,D L . Hence, the functional distributions of $$\dot V_A ,\dot Q$$ , andD L , can be calculated from the time constants. These distribution curves then provide the basis for the determination of the diagnostically important components of the alveolar-arterial pressure difference,AαD, for oxygen and carbon dioxide. In this way, theAαD Distr. 1, which is to be attributed to distribution irregularities in $$\dot V_A /\dot Q$$ , theAαD Distr. 2, which depends upon the value and distribution of $$D_L /\dot Q$$ , and, finally, theAαD sh , determined by the degree of extrapulmonary shunt, can be found.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 78 (1966), S. 595-596 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The complex dielectric constant of aqueous hemoglobin solution was measured at 9.5 GHz. A microwave technique allowing phase and attenuation settings with an accuracy of 0.3° and 0.03 db was used. The shift of the relaxation wavelength and the hydration values of horse hemoglobin were determined for native and lyophilized hemoglobin solution and erythrocytes suspensions as well. The isotope effect of light and heavy water on these parameters was detected. The influence of buffers was studied. Relative measurements, with the sensitivity increased by a factor of 20, were made with alternating oxygenated and deoxygenated human hemoglobin solutions. The oxygenation of hemoglobin was found to leave the hydrated molecule volume invariant within ±250 Å3, while a shift of the relaxation wavelength of 0.0025 ± 0.0015 cm occurs for a hemoglobin concentration of 107 g/l. The results are discussed in terms of the structure and function interrelationship of hemoglobin and the current picture of water structure.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Dielectric dispersion measurements with aqueous solutions of hemoglobin and myoglobin have been performed in the frequency range from 100 kcps to 15 Mcps. The influence of preparation, particle size, and solvent conditions was studied. The results are analyzed in terms of an orientational polarization mechanism.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 5 (1966), S. 586-586 
    ISSN: 0570-0833
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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