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  • 1965-1969  (7)
  • Physics  (4)
  • Life and Medical Sciences  (3)
  • Engineering
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  • 1
    Digitale Medien
    Digitale Medien
    The passage of exogenous peroxidase from blood capillaries into the intestinal epithelium (1967)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 159 (1967), S. 159-169 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Horseradish peroxidase was injected into the spleens of mice and the animals were sacrificed ten minutes after injection. The tissues were reacted with 3-3′ diaminobenzidine hydrochloride and the distribution of the reaction product was studied with both the light and electron microscope. The peroxidase was localized between epithelial cells up to the region of the tight junction and within vacuoles in the absorptive cells Granules ranging in size from ca. 40A to 600A were observed in the cytoplasm of epithelial cells in numbers far in excess of that found in control specimens. It appeared that the diffuse light brown staining observed in epithelial cells with the light microscope could be attributed to large numbers of granules of reaction product free in the cytoplasm. When corn oil was given by stomach tube and an intravascular injection of perioxidase was given ten minutes later, absorbed lipid was found to pass from interepithelial cell spaces to lamina propria at the same time that peroxidase was traversing the same compartments in the reverse direction. Hence, it was shown that exogenous peroxidase and probably other substances of vascular origin required for the metabolism of epithelial cells are exposed to both the basal and lateral epithelial cell membranes, even when absorbed lipid is traversing the same spaces in the opposite direction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091590205
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  • 2
    Digitale Medien
    Digitale Medien
    Marginal zone and germinal center development in the spleens of neonatally thymectomized and nonthymectomized young ratsThis project received support from a General Research Support grant to the University of Wisconsin Medical School from the National Institutes of Health, Division of Research Facilities and Resources. (1968)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 123 (1968), S. 489-499 
    Details
    ISSN: 0002-9106
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Spleens from neonatally thymectomized and nonthymectomized young rats were studied histologically and histochemically to elucidate the development of the splenic immune system with and without thymus.In intact animals primitive germinal center activity could be elicited with antigen as early as 13 days of age. More definitive germinal centers lacking tingible body macrophages were observed at 18 days of age. Germinal centers containing tingible body macrophages did not develop until 35 days of age in response to antigenic stimulation. This coincided with maximal development of the marginal zone of medium-sized lymphocytes and the mature development of nodular macrophages possessing strong acid phosphatase activity.Neonatally thymectomized rats developed marginal zones and germinal centers similar to control littermates when the young animals were maintained on tetracycline. Thymectomized animals not given tetracycline showed disturbances in splenic development. These are discussed.The results suggest that the thymus may be critical to the immune system in rats from birth to about 30 days of age but is not essential to its function beyond this period. Marginal zone lymphocytes and germinal center cells proliferate normally and mature to the plasma cell stage in the absence of a thymus if the animals are maintained on tetracycline beyond this critical age.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aja.1001230306
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  • 3
    Digitale Medien
    Digitale Medien
    A morphological and histochemical study of the primary and secondary immune responses in the rat spleenThis project received support from a General Research Support Grant to the University of Wisconsin Medical School from the National Institutes of Health, Division of Research Facilities and Resources. (1967)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 121 (1967), S. 305-317 
    Details
    ISSN: 0002-9106
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Macrophages and cells of the plasmocyte series were studied in the rat's spleen during the primary and secondary immune responses to particulate antigen. Evidence is presented to suggest that the plasma cell precursors are located in the marginal zones surrounding the lymphoid nodules and that less than one day following injection of antigen, these cells migrate into the nodules, where mitosis and subsequent differentiation into hemocytoblasts occurs in the presence of nodular macrophages. The hemocytoblasts then migrate across the marginal zone into the red pulp where differentiation into mature plasma cells occurs in the presence of red pulp macrophages. It is suggested that the initiation of the antibody-forming process occurs in the lymphoid nodules where marginal zone cells come into close contact with the marginal metalophils or with germinal center macrophages. The process initiating the migration of cells from the marginal zone to the nodules is unknown.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aja.1001210209
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  • 4
    Digitale Medien
    Digitale Medien
    Polymer reactions. V. Kinetics of autoxidation of polypropylene (1967)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 5 (1967), S. 3091-3101 
    Details
    ISSN: 0449-296X
    Schlagwort(e): Physics ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The rate constants for the autoxidation of polypropylene were determined by a combined ESR, volumetric, and chemical method. The values of ki, kp, and kt at 110°C. are 3 × 10-4 sec.-1, 1.9 l./mole-sec., and 3 × 106 l./mole-sec., respectively. The values of ki and its activation energy are the same as those for the decomposition of polypropylene hydroperoxide, thus identifying the latter as the principal initiation process. The values of the temperature-independent kt suggest that secondary peroxy radicals are the terminating species. The rate constants are compared with rate constant ratios for initiated autoxidations of squalane and other related systems.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/pol.1967.150051210
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  • 5
    Digitale Medien
    Digitale Medien
    Polymer reactions. II. Thermal decomposition of polyethylene hydroperoxide (1968)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 6 (1968), S. 375-379 
    Details
    ISSN: 0449-296X
    Schlagwort(e): Physics ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Polyethylene hydroperoxide (PEH) was prepared by low-temperature autoxidation initiated by AIBN. Over 85% of the total hydroperoxyl groups decompose by a rapid process, the remainder dissociate at about one-tenth of that rate. The results are the same whether PEH is decomposed in solution or in the solid state. Large amounts of scavenger have no effect on these decompositions; there is no radical-induced processes. The results suggest mechanisms of decomposition involving neighboring group assistance.
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/pol.1968.150060207
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  • 6
    Digitale Medien
    Digitale Medien
    Polymer reactions. IV. Thermal decomposition of polypropylene hydroperoxides (1968)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 6 (1968), S. 393-402 
    Details
    ISSN: 0449-296X
    Schlagwort(e): Physics ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The thermal decomposition of polypropylene hydroperoxide (PPH) consists of two consecutive reactions. The initial, faster reaction has rates up to 60 times that of the slower process. The former is largely suppressed by the addition of an excess of 2,6-di-tert-butyl-p-cresol. The course of reaction is the same in either solid state or in solution. The results are consistent with an intramolecular radical-induced mechanism for the initial reaction. This faster reaction consumes about 70-95% of the total hydroperoxides. The decomposition of PPH yields a maximum of about 1.8 radicals. Samples prepared from crystalline and amorphous polypropylenes have identical decomposition kinetics.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/pol.1968.150060209
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  • 7
    Digitale Medien
    Digitale Medien
    Polymer reactions. III. Structure of polypropylene hydroperoxide (1968)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 6 (1968), S. 381-392 
    Details
    ISSN: 0449-296X
    Schlagwort(e): Physics ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Oxidation of polypropylene introduces hydroperoxide groups into the polymer. Infrared spectroscopy has determined that more than 90% of these groups are intramolecularly hydrogen bonded. The sequential lengths and sequence distributions of these neighboring hydroperoxides were estimated from the electronic spectra of the polyenes derived from the polypropylene hydroperoxide by two methods: (1) reduction, acetylation, and pyrolysis, and (2) reduction and dehydration. The results indicate that all the hydroperoxide groups are present in sequences of length two and greater. Intramolecular hydrogen abstraction during oxidation could account for the formation of these neighboring hydroperoxides.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/pol.1968.150060208
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