ISSN:
1432-0878
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Electron microscopical studies dealt with the reversible action of Ro4-1284 on norepinephrine and serotonin with respect to the granulated vesicles of the ventromedial hypothalamus and the pineal body of the rat. In the normal rat various types of vesicles were classified according to their size and form. In the hypothalamus two types of granulated vesicles were distinguished from the ungranulated ones. In the pineal gland granular and agranular vesicles have the same diameter; in addition to them large granular vesicles were also to be found. After the application of Ro4-1284 the same types of vesicles appear, which are almost totally deprived of their osmiophilic content. Homogeneous vesicles partially containing membranous bodies remain. The results were interpreted as a visible depletion of norepinephrine and possibly serotonin from their pools which leave behind elements capable of becoming functionally active after the action of the depleting agent.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00337034
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