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  • 1
    Electronic Resource
    Electronic Resource
    N-ACETYLNEURAMINIC ACID MOLECULES AS POSSIBLE SEROTONIN BINDING SITES (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 26 (1976), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 5-Hydroxytryptamine (5-HT), but not acetylcholine, carbamylcholine or L-D-noradrenaline, binds to ox brain ganglioside micelles, to phosphatidylcholine smectic mesophases (liposomes) containing gangliosides and to the glycoprotein fetuin, through the negatively charged N-acctylneuraminic acid (NeuNAc) residues. The 5-HT binding to NeuNAc is reversible, saturable, prodeeds in a 1: 1 fashion and can be specifically blocked by 7-methyltryptamine. Thc affinity constant at equilibrium for the reaction is of the order of 102 1. mol-1. No special ganglioside was identified as specifically associating with the amine. A terminal NeuNAc in the gangliosides is not a prerequisite for binding, although it seems important for binding 5-HT in entire mcmbrane preparations (MARCHBANKS, 1966) or for bringing about the 5-HT induced contraction of smooth muscle cells (WOOLLCY & GOMML 1964a). It is proposed that in 5-HT target cells, NeuNAc residues, probably attached to membrane surface glycoprotein(s) are involved in thc mechanism of action of the drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1976.tb07006.x
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  • 2
    Electronic Resource
    Electronic Resource
    THE ADHESIVENESS OF LEUKOCYTES WITH SPECIAL REFERENCE TO ZETA POTENTIAL (1964)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 116 (1964), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1964.tb52560.x
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  • 3
    Electronic Resource
    Electronic Resource
    Lipid Bilayers and Biomembranes (1972)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 41 (1972), S. 753-776 
    Details
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.bi.41.070172.003541
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  • 4
    Electronic Resource
    Electronic Resource
    Molecular Mechanism of Tay–Sachs Disease (1972)
    [s.l.] : Nature Publishing Group
    Nature 236 (1972), S. 32-33 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Speculation about the pathogenesis of the cytological changes associated with GM2 ganglioside accumulation centres on two possibilities. The observed changes may be due to stereospecific characteristics of the GM2 head-group, or, alternatively, to less specific physicochemical properties of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/236032a0
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  • 5
    Electronic Resource
    Electronic Resource
    Distillation and Storage of Water (1972)
    [s.l.] : Nature Publishing Group
    Nature 237 (1972), S. 408-408 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 The ultraviolet spectra of aqueous extracts of various materials compared with equilibrium water. Trace A is the instrument base line with equilibrium water in both sample and reference cuvettes; B, ?Viton? rubber tubing; C, polyvinyl chloride tubing; D, Tarafilm' closure material; E, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/237408a0
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  • 6
    Electronic Resource
    Electronic Resource
    Physical and physiological properties of dry lung surfactant (1978)
    [s.l.] : Nature Publishing Group
    Nature 271 (1978), S. 162-163 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The critical micelle concentration (CMC) of the principal lung surfactant phospholipid, L-a-dipalmitoyl phosphatidyl-choline, in water has the extremely low value of 4.6±0.5 x 1010M (ref. 2). In consequence the overwhelmingly preferred domain for a single phospholipid molecule in water is in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/271162a0
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  • 7
    Electronic Resource
    Electronic Resource
    Negatively Stained Lipoprotein Membranes (1963)
    [s.l.] : Nature Publishing Group
    Nature 200 (1963), S. 1340-1340 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] During the examination of sub-cellular components2 a comparison was made between: (a) unfixed negatively stained preparations; (b) preparations fixed with either formaldehyde or osmium tetroxide, followed by negative staining; and (c) conventional thin sections4, 5. Owing to the low osmolarity of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2001340a0
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  • 8
    Electronic Resource
    Electronic Resource
    Very Long-range Structuring of Liquids, including Water, at Solid Surfaces (1968)
    [s.l.] : Nature Publishing Group
    Nature 219 (1968), S. 1151-1152 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] From Reference 2 "The adsorption isothermals of benzene and methyl alcohol vapours at the surface of mica are of sigmoid form, concave to the pressure axis until the first mono-layer is nearing completion, and thereafter becoming more and more steeply inclined to it as saturation is approached. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2191151a0
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  • 9
    Electronic Resource
    Electronic Resource
    Action of Saponin on Biological Cell Membranes (1962)
    [s.l.] : Nature Publishing Group
    Nature 196 (1962), S. 952-953 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE tacit assumption made by Dourmashkin, Dougherty and Harris1 to explain the hexagonal structure of some virus and mammalian cells treated with saponin was that, by removal of certain lipid components, an ordered membrane structure was revealed. Schulman and Rideal2, however, showed that saponin ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/196952a0
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  • 10
    Electronic Resource
    Electronic Resource
    Penetration of Lipid Films by Compounds Preventing Liver Necrosis in Rats (1962)
    [s.l.] : Nature Publishing Group
    Nature 193 (1962), S. 754-756 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A LARGE number of substances have been found to possess the property of preventing liver necrosis in the rat following thioacetamide or carbon tefcrachloride poisoning1-3. These compounds include such diverse materials as antihistamines. local anaesthetics and antioxidants. It appears that at least ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/193754a0
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