ISSN:
1432-8798
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Six plaque types all belonging to the same antigenic group (E54) of vesicular exanthema of swine virus (VESV) were studied for mutational changes in swine and in pig and canine cell cultures. The plaque types differed in virulence, the largest in size being the most virulent and the smallest the least virulent type. Neutralization tests revealed that only animals which showed frank disease developed specific viral antibodies. The inoculated type was generally mixed with other plaque types after recovery from the host. The contaminating new types were not the same for the different plaque type inoculations. Similar changes were observed in the two types of cell cultures. Since all inocula consisted of virus from single cell yields which were clonal in origin, it was concluded that mutational changes occurredin vivo andin vitro. Such mutations, together with the requisite selective forces, could lead to erroneous classification of a variant in regard to virulence.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01250145
Permalink
