ISSN:
0003-276X
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
Normal parathyroid glands exhibited two distinct cellular types: one type of cell had a large round nucleus containing fine chromatin granules and a nucleolus; the other type had a round or spindle-shaped nucleus with densely-packed chromatin. The following hormonal preparations were tested and failed to alter parathyroid histology: relaxin extract (R), estradiol cyclopentylpropionate (ECP), combined ECP and R, or various combinations of these hormones with progesterone or cortisone acetate. The pubic joints of the mice underwent the anticipated hormonally-induced changes. Our results are at variance with those of Chase and Shanmugasundaram ('64) who (a) described only one cell type in the mouse parathyroid and (b) reported that relaxin alone or a combination of estrogen and relaxin induced cellular changes suggestive of increased glandular function. The two studies are apparently irreconcilable; however, we did note in about 30% of our mice variable lymphatic aggregates in the thyro-parathyroid complex. Although not actually related to hormonal treatments, it is conceivable that in a small series of animals and without serial sectioning, such lymphatic tissue might be mistaken for altered parathyroid gland.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/ar.1091530302
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