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  • 1
    Digitale Medien
    Digitale Medien
    TETANUS TOXIN AND AMINO ACID LEVELS IN CAT SPINAL CORD (1969)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 16 (1969), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract— —The levels of the depressant amino acids found in appreciable amounts in cord extracts—α-alanine, cystathionine, GABA, glycine and serine—were not significantly influenced by tetanus toxin. This supports the view that the antagonism of spinal inhibition by the toxin is the result of an interference with transmitter release rather than a reduction in the amount of transmitter available for release.The marked increase in aspartic acid levels found in the spinal cord after treatment with tetanus toxin may reflect the association of aspartic acid with the increased activity of spinal excitatory interneurones or the involvement of aspartic acid as a glycine precursor in spinal tissue.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1969.tb06459.x
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  • 2
    Digitale Medien
    Digitale Medien
    Central Synaptic Transmission-Microelectrophoretic Studies (1969)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 9 (1969), S. 209-240 
    Details
    ISSN: 0362-1642
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Medizin , Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.pa.09.040169.001233
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  • 3
    Digitale Medien
    Digitale Medien
    Central Effects of β- N -Oxalyl-α,β-diaminopropionic Acid and other Lathyrus Factors (1966)
    [s.l.] : Nature Publishing Group
    Nature 211 (1966), S. 637-637 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Action potentials were recorded extracellularly from spinal interneurones and Betz cells by means of the centre barrel of five-barrel glass micropipettes of overall tip diameter 4-5fx, while the compounds under investigation were administered electrophoretically into the immediate extracellular ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/211637a0
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  • 4
    Digitale Medien
    Digitale Medien
    A Central Action of Hemicholinium (1965)
    [s.l.] : Nature Publishing Group
    Nature 208 (1965), S. 192-194 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] The experiments were performed in the lumbar segments of spinal cats anaesthetized with pentobarbital sodium. Renshaw cells were activated synaptically by volleys in the appropriate segmental ventral or dorsal roots, and extracellular spike potentials (negative-positive, 100-1,000 [iV in amplitude) ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/208192a0
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  • 5
    Digitale Medien
    Digitale Medien
    Acetylcholine Sensitivity of Cerebellar Neurones (1965)
    [s.l.] : Nature Publishing Group
    Nature 206 (1965), S. 516-517 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] However, recent work on the distribution of acetyl-cholinesterase in the feline cerebellum has shown that this enzyme is confined to the granular layer4. If the location is similar to that of the rat, in which acetylcholin-esterase is related to mossy fibres from reticular nuclei5, then such ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/206516a0
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  • 6
    Digitale Medien
    Digitale Medien
    Strychnine and Cortical Inhibition (1967)
    [s.l.] : Nature Publishing Group
    Nature 214 (1967), S. 914-915 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] When administered electrophoretically strychnine has complex actions on mammalian nerve cells. Renshaw cells are excited by concentrations which exceed those adequate to block postsynaptic inhibition; with higher concentrations the extracellularly recorded action potentials are reduced in amplitude ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/214914a0
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  • 7
    Digitale Medien
    Digitale Medien
    Inhibition of Spinal Neurones by Glycine (1967)
    [s.l.] : Nature Publishing Group
    Nature 215 (1967), S. 1502-1503 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] There are considerable difficulties in determining whether the postsynaptic action of glycine is identical with that of the inhibitory transmitter, although both substances clearly hyperpolarize motoneurones. The measurement of "reversal" potentials by passing current through an intracellular ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/2151502a0
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  • 8
    Digitale Medien
    Digitale Medien
    Acetylcholine, Strychnine and Spinal Inhibition (1967)
    [s.l.] : Nature Publishing Group
    Nature 215 (1967), S. 1503-1503 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] An opportunity has been taken to test this hypothesis on spinal neurones for which there is very good evidence that acetylcholine is an excitatory transmitter. The pharmacology of the excitation of Rerishaw cells by impulses in motor axon collaterals bears some resemblance to that of cholinergic ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/2151503a0
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  • 9
    Digitale Medien
    Digitale Medien
    The depression of spinal inhibition by morphine (1969)
    Springer
    Inflammation research 1 (1969), S. 14-19 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Electrophoretically administered morphine and codeine, but not meperidine, blocked the inhibitory effect of glycine on spinal neurones, without reducing the effectiveness of GABA. This action of morphine was similar to, but much weaker than, that of strychnine. When administered intravenously in divided doses to circumvent marked circulatory disturbances, morphine reduced the direct and recurrent inhibition of spinal motoneurones in a parallel fashion. Again morphine was a very weak strychnine-like substance, doses in excess of 50 mg/kg being required to block these disynaptic spinal inhibitions. The results are not incompatible with the function of a glycine-like amino acid as the inhibitory transmitter for both the direct and recurrent spinal inhibitory pathway.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01990015
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  • 10
    Digitale Medien
    Digitale Medien
    A pharmacological study of the depression of spinal neurones by glycine and related amino acids (1968)
    Springer
    Experimental brain research 6 (1968), S. 1-18 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Glycine ; GABA ; Spinal postsynaptic inhibition ; Strychnine ; Enzyme inhibition
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary An analysis has been made in anaesthetised cats of the depression by glycine and related amino acids of the firing of spinal dorsal horn interneurones, Renshaw cells and cortical neurones. In general, electrophoretically administered glycine was a more potent depressant of interneurones than GABA. The reverse was true for cortical neurones, whereas these two amino acids were approximately equally effective upon Renshaw cells. Strychnine blocked the depressant action of α- and β-amino acids, but not that of γ- and higher ω-amino acids. Only convulsants having a strychnine-like effect on spinal post-synaptic inhibition blocked the action of glycine. The depression of spinal neurones produced by glycine or GABA was not affected by structural analogues of glycine and GABA that were not depressants, or by substances influencing amino acid transport systems. Some evidence was obtained for the enzymic inactivation of electrophoretically administered glycine in spinal tissue. The results are discussed in terms of the involvement of a glycine-like amino acid as a major spinal inhibitory transmitter.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00235443
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