ISSN:
0021-9304
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
,
Technology
Notes:
A number of inhibitors of intrinsic blood coagulation have been examined. Particular emphasis was placed on heparin, heparin analogues, and hirudin. These inhibitors interfere primarily with two clotting factors in the intrinsic clotting scheme. These include factor IXa and thrombin. Our data suggest that factor IXa is the heparin-and hirudin-sensitive factor in plasma when coagulation is initiated via factors XII or XI, and that subsequent clotting factors remain in inactive forms. Studies with heparin and hirudin also clarified the role of thrombin in the interaction of factors IXa and VIII. It was concluded from these experiments that factor VIII readily interacts with factor IXa in the presence of calcium ions and phospholipid independent of thrombin.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jbm.820030109
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