ISSN:
0003-276X
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
Chick embryos were inoculated with influenza-A virus over the blastoderm at 42-50 hours incubation (37°C). Surviving embryos were harvested 24 hours later, Grossly and microscopically, the developing brain exhibits a type of abnormality in which the neural wall is highly convoluted with folds projecting into the ventricular cavities, suggesting “overgrowth” of the neural tissue.A comparison of measurements on projection drawings of serial sections of virus inoculated and control embryos at comparable developmental stages indicates that the ventricular surface area, volume of brain tissue and volume of the ventricular cavity are markedly less in the experimental embryos, but average thickness of the brain wall is greater. There are fewer nuclei and mitotic figures in experimental embryos, although average nuclear and mitotic densities and mitotic index are approximately the same as control values.It is evident that the characteristic neural defect is not due to excessive growth, since the volume of brain tissue and number of cells are consistently less in experimental embryos. It is concluded that the virus infection results in an inhibition of growth of the brain wall, and that the increased thickness and foldings must result from collapse of the brain which in turn may be due to a decrease in the amount of ventricular fluid.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/ar.1091580102
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