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Die Wirkung von g-Strophanthin auf den Papillarmuskel der Katze bei Hypothermie, Normaltemperatur und Hyperthermie (1962)

Meyer, Hubert F. ; Kukovetz, Walther R.

Springer

Naunyn-Schmiedeberg's archives of pharmacology 242 (1962), S. 409-413

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ISSN: 1432-1912

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary 1. Isometric systolic tension (I.S.T.) was measured in the papillary muscle of the cat-heart at temperatures of 37° C, 27° C and 41° C, before and after administration of g-Strophanthine. 2. In the majority of experiments an increase in temperature was associated with a decrease of I.S.T. 3. g-Strophanthine in concentrations of 0.05–0.2 μ/ml increased the I.S.T. of the failing papillary muscle at 37° C, but did not change the I.S.T. at 27° C and 41° C. 4. It is assumed that induction of hypothermia as such compensates for the failure of the papillary muscle which is necessary for the action of cardiac glycosides.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00247965

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