ISSN:
1432-1912
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary 1. The influence of serotonin on the absorption of tritiated water (HTO) from the small intestine of rats was studied in situ. 2. Serotonin given intraluminally (2,5 mg) or by intravenous infusion (5 ώg/min) reduced the speed of water absorption to about 50%. This effect may be caused by a change in intestinal capillary blood flow or an inhibition of active water transport. 3. When serotonin was infused intravenously, but not when it was given into the intestinal lumen, the concentration of HTO in blood was found to be higher than in the controls. This reduction of HTO space can be explained by concomitant vasoconstriction. 4. It is assumed that the delay of water transport by serotonin contributes to the occurrence of waterly diarrhoea in carcinoid patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00245413
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