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  • 1955-1959  (3)
  • Chemistry  (3)
  • 42.60B
  • Chemical Engineering
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  • 1
    Electronic Resource
    Electronic Resource
    Über einige β-substituierte Fettsäureamide mit lokalanästhetischer Wirkung (1955)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 38 (1955), S. 1085-1095 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The preparation and properties of further fatty acid anilides showing anaesthetic action are described and the relationship between chemical constitution and physiological effect is discussed. Two very active compounds having relatively low toxicities have been discovered, namely:-β-piperidino-n-butyric-acid-2,4-dichloranilide (XIV) and β-(2-methylpiperidino)-n-butyric-acid-anilide (V). A number of similar anilides show high activities, but other undesirable properties such as tissue irritation render them less useful.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19550380502
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Über einige β-substituierte Fettsäureamide mit lokalanästhetischer Wirkung. 4. Mitteilung (1959)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 42 (1959), S. 1764-1771 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The preparation and properties of some new β-alkylamino-butyric anilides have been described and a summary report on some of their pharmacological properties is given. Two derivatives (the p-(carbo-n-butoxy)-anilides of β-diethylamino- and of β-(1-piperidino)- butyric acid = XVI and XVIII) show promise as very active local anaesthetics with low toxicities. One derivative (β-N-pyrrolidino-n-butyric acid anilide = XXVII) shows strong potentiation of the sedative properties of barbiturates.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19590420603
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Über einige β-substituierte Fettsäureamide mit lokalanästhetischer Wirkung. 5. Mitteilung (1959)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 42 (1959), S. 1771-1779 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A further series of butyric acid amides has been synthesised in which the diethylamino, pyrrolidino and piperidino groups of previously reported syntheses have been substituted by morpholino groups. The influence of the various groups in the present and in previously reported derivatives on the pharmacology of the series is reported and summarised. The conditions necessary for maximum local anaesthesia and barbiturate potentiation are discussed.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19590420604
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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