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Failure of (+)-naloxone to accelerate feline colonic transit (1990)

Krevsky, B. ; Fisher, R. S. ; Cowan, A.

Springer

Cellular and molecular life sciences 46 (1990), S. 217-219

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ISSN: 1420-9071

Keywords: (−)-Naloxone ; (+)-naloxone ; cat ; transit ; scintigraphy ; colon

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary To determine whether the colonic transit accelerating effect of (−)-naloxone (0.3 mg/kg, i.m.) is due to an action at opioid receptors or a direct pharmacologic effect, its enantiomer, (+)-naloxone (0.3 mg/kg, i.m.) was administered to cats and compared to saline control using colonic transit scintigraphy. Transit was not accelerated by (+)-naloxone. The effects of naloxone on colonic transit are thus stereospecific, and are probably mediated by opioid receptors.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02027320

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