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  • (Chicken oviduct)  (1)
  • Audiogenic seizures  (1)
  • Chemistry  (1)
  • 1
    Electronic Resource
    Electronic Resource
    ZK98299, a novel antiprogesterone that does not interact with chicken oviduct progesterone receptor
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Molecular Cell Research 1094 (1991), S. 185-192 
    Details
    ISSN: 0167-4889
    Keywords: (Chicken oviduct) ; Antiprogesterone ; Progesterone receptor
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0167-4889(91)90007-K
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    An experimental evaluation of dependence liability of methaqualone diphenhydramine (combination) and methaqualone in rats (1980)
    Springer
    Psychopharmacology 67 (1980), S. 203-207 
    Details
    ISSN: 1432-2072
    Keywords: Methaqualone and diphenhydramine ; Methaqualone ; Tolerance ; Physical dependence ; Audiogenic seizures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the present study the drugs (Methaqualone + diphenhydramine or Methaqualone alone) were administered daily in a liquid diet to different groups of rats for 3 weeks. Each week the doses of the drugs were increased and daily records of body weight, mean rectal temperature and spontaneous motor activity (SPM) were maintained. During the first week, tolerance to both the drugs was observed when the animals received 152.4 mg/kg-1/day of methaqualone (MQ) and 140.0+14.0 mg/kg-1/day of methaqualone + diphenhydramine (MQ+D) respectively. In the second week the doses were further increased to 302.0 mg/kg-1/day of MQ and 277.8+27.7 mg/kg-1/day of MQ+D respectively. At the end of the second week complete tolerance developed to increased doses of MQ but not to the MQ+D combination. In the third week the doses were further increased to 406.6 mg/kg-1/day of methaqualone and 383.4+38.3 mg/kg-1/day of MQ+D respectively. At the end of this week although there was partial recovery but, compared to the controls, a significant lowering (P〈0.05) of mean rectal temperature and spontaneous motor activity persisted in both groups thus showing an incomplete tolerance to larger doses of both MQ and the MQ+D combination. When the drugs were withdrawn after the third week, both MQ as well as MQ+D treated groups of rats exhibited an increased susceptibility to audiogenic stimuli of, but MQ+D treated animals showed an even greater susceptibility to such stimuli and also a fall in body weight. Further, 50% of rats in MQ+D group died during convulsions while there were no deaths in the group treated with MQ alone. The results of this study suggest that the MQ+D combination causes a more severe degree of physical dependence than MQ alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431978
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Evolutionary synthesis of separation processes (1981)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 27 (1981), S. 578-587 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: This paper deals with the problem of finding, among many alternatives, the sequence of separation units that will isolate desired products from given feed at the minimum cost. Multicomponent products can be specified. An evolutionary procedure is presented. This method consists of two phases. In the first phase, a good initial structure is created by heuristic methods. In the second phase, the initial structure is successively modified by making evolutionary structural changes. This logic has been programmed on a digital computer and has been tested on several problems.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690270407
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    Paper (German National Licenses)
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