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  • Crystal Structure  (2)
  • Urogynecology  (2)
  • (Dichloromethylene)bisphosphonate  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Enhanced tumour growth in the rat liver after selective elimination of Kupffer cells (1993)
    Springer
    Cancer immunology immunotherapy 37 (1993), S. 125-130 
    Details
    ISSN: 1432-0851
    Keywords: Liposomes ; (Dichloromethylene)bisphosphonate ; Kupffer cells ; Metastatic growth ; Liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The evidence that Kupffer cells are capable of controlling metastatic growth in the liver in vivo is largely circumstantial. The best approach when studying natural cytotoxicity activities of Kupffer cells is to investigate the effect of Kupffer cell elimination on tumour growth. Until now it has not been possible to eliminate Kupffer cells without affecting other cell populations. We have recently developed a new method to eliminate Kupffer cells selectively: intravenous injection of liposome-encapsulated (dichloromethylene)bisphosphonate (Cl2MDP-liposomes) leads to effective elimination of all Kypffer cells, without affecting non-phagocytic cells. Wag/Rij rats were injected with Cl2MDP-liposomes. After 48 h, rats were inoculated with syngeneic CC531 colon carcinoma cells by injection in the portal system. The results show a strongly enhanced tumour growth in the liver of the Cl2MDP-liposometreated rats. In these animals, livers were almost completely replaced by tumour and had increased in weight, whereas in the control groups only a few (four to eight) small (1-mm) tumour nodules were found. These data show that selective elimination of Kupffer cells results in enhanced tumour growth in the liver, implying that Kupffer cells play a crucial role in controlling tumour growth in the liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01517045
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  • 2
    Electronic Resource
    Electronic Resource
    The correlation between historical, clinical and urodynamic parameters in patients suffering from genuine stress urinary incontinence: Can a severity grading be considered? (1995)
    Springer
    International urogynecology journal 6 (1995), S. 337-342 
    Details
    ISSN: 1433-3023
    Keywords: Urinary incontinence ; Urodynamic ; Urogynecology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the study was to determine the possibility of establishing a genuine stress urinary incontinence severity grading from the combination of historical clinical and urodynamic parameters. Four hundred and eighty-three patients underwent complete investigation, including a questionnaire, clinical evaluation and multichannel urodynamic testing. They were then divided into four groups on the basis of the presence of only a SUI history (group 1,n=65); positive urine loss with a ‘continent’ stress urethral pressure profile (SUPP) (group 2,n=61); positive urine loss with an ‘incontinent’ SUPP (group 3,n=231); or no urine loss with an ‘incontinent' SUPP (group 4,n=126). Compared to group 1 the severity of incontinence was significantly greater in groups 2 and 3. and maximal urethral closure pressure and pressure transmission ratio were significantly reduced in group 3 and 4. Otherwise, history, clinical and urodynamic parameters showed no significant differences between the four groups. It was concluded that a scoring severity can be established when considering all the parameters of a woman suffering from GSI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01892739
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  • 3
    Electronic Resource
    Electronic Resource
    The assessment of bladder neck position and mobility in continent nullipara, mulitpara, forceps-delivered and incontinent women using perineal ultrasound: A future office procedure? (1996)
    Springer
    International urogynecology journal 7 (1996), S. 138-146 
    Details
    ISSN: 1433-3023
    Keywords: Bladder neck ; Perineal ultrasound ; Stress incontinence ; Urogynecology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this study was to assess the effects of spontaneous and instrumented deliveries, the baby's birthweight, the presence of stress incontinence and the woman's age and weight on bladder neck (BN) position and mobility using perineosonography, a simple non-invasive method, and to compare these results with those from continent nulliparous controls. Two hundred and fourteen women, including 74 nullipara, 29 para-1, 64 para-2 and 3, 16 with previous forceps deliveries and 32 with stress incontinence, underwent perineosonography with measurements of BN position and backwards/downwards displacement of BN using a two-axis calculation system. Results showed that bladder neck position undergoes a significantly backwards and downwards displacement on assuming an upright position. When compared with nulliparous controls, the bladder neck position at rest was the same in all groups of parous women in the supine/standing positions, but lower in patients having undergone forceps delivery (standing position) and in stress incontinent patients (both supine and standing); the bladder neck position during Valsalva was significantly lower in all groups of patients in the standing position, but the only significant difference in the supine position was seen in stress incontinent patients; the extent of bladder neck displacement was not significantly different between the groups, except in stress incontinent patients. A strong correlation (r=0.66) was found between the relative importance of backwards and downwards displacement, but no correlation was found between bladder neck displacement and baby's birthweight or patient's weight. It was concluded that compared to nulliparous continent patients, normal and instrumented delivery induces no modifications of BN position at rest, but is responsible for a lower bladder neck position during Valsalva in the standing position only. The extent of BN displacement is virtually the same in all groups of patients in both positions, except for stress incontinent patients, who have a significantly lower and more mobile bladder neck, the values of which overlap to a great extent (sensitivity of 78%/75% for a displacement 〉14 mm) within those seen in continent nulliparous women. The correlation between the importance of backwards and downwards displacement is strong, making superfluous a two-dimensional coordinate system for routine BN position/mobility assessment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01894202
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  • 4
    Electronic Resource
    Electronic Resource
    Zur Kenntnis von Ba6Pr2Fe4O15, Ba5SrPr2Fe4O15 und Ba5CaPr2Fe4O15 (1997)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 623 (1997), S. 200-204 
    Details
    ISSN: 0044-2313
    Keywords: Alkaline Earth ; Praseodym ; Iron Oxide ; Crystal Structure ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: On Ba6Pr2Fe4O15, Ba5SrPr2Fe4O15 and Ba5CaPr2Fe4O15Ba6Pr2Fe4O15 (I), Ba5SrPr2Fe4O15 (II), and Ba5CaPr2Fe4O15 (III) have been prepared by high temperature CO2-LASER techniques. (I)-(III) crystallize isotypic to the Ba6Ln2Al4O15 type, space group C6v4-P63mc, (I): a = 11.808(2), c = 6.894(5), Z = 2. Typical features of the crystal structure are face shared MO6 octahedra (M = Ba or Ba/Sr, Ba/Ca) and a statistical distribution of Ba and Pr in a ratio of 1 : 2 within double capped trigonal prisms of oxygen. Fe shows tetrahedral as well as octahedral coordination by oxygen. Calculation of coulomb terms of lattice energy indicate the stabilization of Pr3+ beside Fe3+ by the Ba6Ln2Al4O15 type.
    Notes: Ba6Pr2Fe4O15 (I), Ba5SrPr2Fe4O15 (II) und Ba5CaPr2Fe4O15 (III) wurden mit Hochtemperatur-CO2-LASER-Technik dargestellt. (I)-(III) kristallisieren mit hexagonaler Symmetrie, Raumgruppe C6V4-P63mc, (I): a = 11.808(2), c = 7,036(4) Å; (II): a = 11.689(2), c = 6.954(2) Å; (III): a = 11.602(6), c = 6.894(5) Å, Z = 2. Charakteristische Eigenschaften dieser Kristallstruktur sind flächenverknüpfte MO6-Oktaeder (M = Ba oder Ba/Sr, Ba/Ca) und eine statistische Verteilung von Ba und Pr im Verhältnis 1 : 2 in einem zweifach überkappten trigonalen Sauerstoffprisma. Fe zeigt sowohl tetraedrische als auch oktaedrische Sauerstoffkoordination. Berechnungen der Coulomb-Terme zur Gitterenergie deuten an, daß durch den Ba6Ln2A4O15-Typ Pr3+ neben Fe3+ stabilisiert wird.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19976230133
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  • 5
    Electronic Resource
    Electronic Resource
    Cu4O12-Baugruppen aus planaren CuO4-Polygonen im Barium-Vanadyl-Oxocuprat(II)-phosphat Ba(VO)Cu4(PO4)4Professor Rudolf Hoppe zum 75. Geburtstag gewidmet (1997)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 623 (1997), S. 1693-1698 
    Details
    ISSN: 0044-2313
    Keywords: Barium ; Copper ; Vanadyl Phosphate ; Crystal Structure ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Cu4O12 Groups Built of Square Planar CuO4 Polygones in the Barium Vanadyl Oxocuprate(II) Phosphate Ba(VO)Cu4(PO4)4Single crystals of Ba(VO)Cu4(PO4)4 have been prepared by solid state reactions just below the melting points of the reaction mixtures of BaP2O6, Cu3(PO4)2, CuO, V2O5 and V2O3 in evacuated closed quartz glas tubes. The compound crystallizes with tetragonal symmetry, Space group D42—P4212, a = 9.560(2), c = 7.160(2) Å, Z = 2. Special and new features of the crystal structure are to each other isolated Cu4O12 and (VO)(PO4)4 groups. The crystal chemistry of the Cu4O12 groups is discussed with respect to other compounds containing out of plane connected square planar MO4 polygones.
    Notes: Einkristalle von Ba(VO)Cu4(PO4)4 wurden mit Festkörperreaktionen dicht unterhalb des Schmelzpunktes des Reaktionsgemenges aus BaP2O6, Cu3(PO4)2, CuO, V2O5 und V2O3 in geschlossenen, evakuierten Quarzglasampullen dargestellt. Diese Verbindung kristallisiert tetragonal, Raumgruppe D42—P4212, mit a = 9,560(2), c = 7,160(2) Å, Z = 2. Besondere und neue Eigenschaften der Kristallstruktur sind zueinander isolierte Cu4O12- und (VO)(PO4)4-Gruppen. Die Kristallchemie der Cu4O12-Baugruppen wird mit Blick auf andere Verbindungen, die nicht in Ebenen verknüpfte MO4-Polygone aufweisen, diskutiert.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19976231103
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