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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 692 (1982), S. 361-370 
    ISSN: 0005-2736
    Keywords: (Rabbit erythrocyte) ; Glycophorin ; Hemoglobin binding site
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Rechtsmedizin 9 (1999), S. 81-85 
    ISSN: 1434-5196
    Keywords: Key words Gastric ulcer ; Duodenal ulcer ; Bleeding ; Perforation ; Haematemesis ; Melaena ; Sudden death ; Schlüsselwörter Ulcus ventriculi ; Ulcus duodeni ; Blutung ; Perforation ; Hämatemesis ; Melaena ; Plötzlicher Tod
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Es erfolgte die retrospektive Auswertung der im Zeitraum von 1991–1997 am Institut für Rechtsmedizin der Universität Hamburg durchgeführten 6962 gerichtlichen und wissenschaftlichen Obduktionen hinsichtlich erst autoptisch identifizierter gastroduodenaler Ulzera als Ursache des plötzlichen, unerwarteten Todes. Dabei fanden sich 25 Fälle (58%) mit tödlicher Blutung, 16 Fälle (37%) todesursächlicher Perforation und 2 Fälle mit einer Koinzidenz von Blutung und Perforation. Insgesamt lag die Prävalenz letaler Komplikationen gastroduodenaler Ulzera im untersuchten Sektionsgut bei 0,62%. Folgende Aspekte sind hervorzuheben: Als Ursache des plötzlichen, unerwarteten Todes betreffen gastroduodenale Ulzera vorwiegend ältere Menschen (Durchschnittsalter der Betroffenen im untersuchten Obduktionsgut 62,2 Jahre), Angehörige sozialer Randgruppen und Abhängigkeitskranke (vorrangig Alkoholabusus). Bei fehlenden oder atypischen Krankheitssymptomen kommt es nicht selten zu ärztlichen Fehleinschätzungen der vitalen Bedrohung und unzureichender medizinischer Diagnostik.
    Notes: Abstract A retrospective review of 6962 autopsies carried out at the Institute of Legal Medicine (University of Hamburg) during 1991–1997 was performed to identify previously unknown peptic ulcer disease as the cause of sudden, unexpected death. During this period 25 cases (58%) of fatal acute bleeding, 16 cases (37%) of fatal peptic ulcer perforation and 2 cases of coincident bleeding and perforation occurred. The following aspects are emphasized: as the cause of sudden, unexpected death peptic ulcer disease mainly affects elderly people (average of the afflicted in the reviewed autopsy series 62.2 y), members of social fringe groups and addicts (predominately alcoholics). In cases of absent or atypical symptoms, preceding false medical appraisal of the life-threatening severity of the disease and insufficient diagnoses can be frequently found.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1434-5196
    Keywords: Schlüsselwörter Bakterielle Meningitis ; Posttraumatische Meningitis ; Plötzlicher Tod ; Streptococcus pneumoniae ; OPSI-Syndrom ; Waterhouse-Friderichsen-Syndrom ; Postmortale ; mikrobiologische Diagnostik ; Keywords Bacterial meningitis ; Posttraumatic meningitis ; Sudden death ; Streptococcus pneumoniae ; OPSI-syndrome ; Waterhouse-Friderichsen syndrome ; Postmortem microbiological diagnostics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Between 1992 and 1999, 20 cases of a previously undiagnosed meningitis (10 males, mean age 49.2 years; 10 females, mean age 53.4 years) out of a total of 8305 autopsies were identified, corresponding to a frequency of 0.23% in the reviewed autopsy material. In 8 cases, the deceased seeked medical advice shortly before death due to unspecific complaints. In 10 cases, a peracute course of the disease was considered retrospectively. Affected persons under 40 years of age frequently died in hospital whereas persons over 60 years of age died more often in their domestic environment. At the onset of symptoms, persons between 40 and 60 years of age complained of headaches and indisposition significantly more often than persons under 40 years or over 60 years of age. Postmortem swabs of the leptomeninx resulted in cultural growth of pathogenetic germs in 12 out of 14 cases examined (Streptococcus pneumoniae n = 8; Neisseria meningitidis (capsular type C) n = 2; Staphylococcus aureus n = 1; Streptococcus pyogenes n = 1). Most frequent concomitant diseases diagnosed at autopsy were acute tracheobronchitis, pneumonia and purulent sinusitis but in general a definitive identification of the entry site of bacteria is not possible postmortem. Histomorphologically, the predominant type was tegmental meningitis with a mixed polymorphonuclear cell infiltrate. In the forensic elucidation of fatalities due to meningitis, questions concerning medical malpractice can be raised (e. g. misdiagnosis, late diagnosis). In cases with preceding craniocerebral trauma, the forensic expert is confronted with the question of causality between trauma and death.
    Notes: Unter den im Zeitraum von 1992–1999 am Institut für Rechtsmedizin der Universität Hamburg durchgeführten 8305 gerichtlichen und wissenschaftlichen Obduktionen fanden sich 20 Fälle (männliches Geschlecht n = 10, Durchschnittsalter 49,2 Jahre; weiblich n = 10, Durchschnittsalter 53,4 Jahre) erst autoptisch diagnostizierter bakterieller Meningitiden. Dies entspricht einer Häufigkeit von 0,23% im untersuchten Sektionsgut. In 8 Fällen befanden sich die Verstorbenen kurz vor dem Tode wegen unklarer Beschwerden in ärztlicher Behandlung, in 10 Fällen konnte der Verlauf retrospektiv als perakut eingeordnet werden. Erkrankte im Alter 〈 40 Jahre verstarben weit häufiger im Krankenhaus als Erkrankte des Alters 〉 60 Jahre, die überwiegend zu Hause verstarben. Erkrankte im Alter zwischen 40 und 60 Jahren zeigten signifikant häufiger Kopfschmerzen und Unwohlsein als initiale Symptome als Erkrankte mit einem Alter von 〈 40 Jahren und 〉 60 Jahren. Ein postmortaler Erregernachweis von Abstrichen der Leptomeninx gelang in 12 von 14 diesbezüglich untersuchten Fällen (Streptococcus pneumoniae n = 8; Neisseria meningitidis, Kapseltyp C n = 2; Staphylococcus aureus n = 1; Streptococcus pyogenes n = 1). Häufigste autoptisch festgestellte Begleiterkrankungen waren eitrige Tracheobronchitis, Pneumonie und eitrige Sinusitis, wobei eine definitive Feststellung der Eintrittspforte der Erreger am Autopsiematerial in der Regel nicht möglich ist. Histomorphologisch dominierte der Typ der Haubenmeningitis mit vorwiegend gemischtzelliger Entzündungsreaktion. Bei der forensischen Beurteilung von Meningitistodesfällen kann neben der Verkennung der Erkrankung vor dem Hintergrund evtl. unzureichender ärztlicher Diagnostik insbesondere der Prognose in Abhängigkeit vom Zeitpunkt der korrekten Diagnosestellung unter straf- und zivilrechtlichen Aspekten Bedeutung zukommen. Auch wirft die Anamnese eines vorausgegangenen Schädel-Hirn-Traumas aus rechtsmedizinischer Sicht Fragen hinsichtlich des Kausalzusammenhangs auf.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Rechtsmedizin 10 (2000), S. 166-169 
    ISSN: 1434-5196
    Keywords: Schlüsselwörter Asthma bronchiale ; Status asthmaticus ; Rechtsherzversagen ; Plötzlicher Tod ; Keywords Bronchial asthma ; Status asthmaticus ; Right heart failure ; Sudden death
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Abstract Asthma is a widespread disease with an increasing prevalence. In spite of improved therapeutic strategies some cases can still take a fatal course. A total of 21 cases of acute death in asthmatics were analysed ¶(12 females and 9 males, aged between ¶2 and 75 years old), whereby 18 cases happened at home (mostly at night), 1 in a hospital, 1 in a nursing-home and 1 in a prison. ¶A history of asthmatic attacks, chronic asthmatic lesions and signs of acute airway obstruction and right cardiac failure were characteristic for all cases. Forensic investigations included questions of external violence, intoxication or incorrect medical treatment.
    Notes: Zusammenfassung Dargestellt werden 21 akute Asthma-Todesfälle von 12 weiblichen und 9 männlichen Personen zwischen 2 und 75 Jahren ohne Häufung in einem bestimmten Lebensalter. Hiervon ereigneten sich 18 Fälle zu Hause (zumeist nachts), einer im Krankenhaus, ¶einer im Pflegeheim und einer in einer Haftanstalt. Die Diagnose eines (chronischen) Asthmas war regelmäßig gestellt. Forensische Fragen zielten auf einen Ausschluss von Fremdverschulden oder eines ärztlichen Behandlungsfehlers.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 95 (1962), S. 3084-3085 
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 92 (1959), S. 1055-1062 
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Gleichgewichtslage der Isomerisierungsreaktion Propin ⇌ Propadien wurde im Temperaturbereich von 100 bis 370° unter Zuhilfenahme der Infrarotspektroskopie ermittelt.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 177 (1976), S. 1687-1693 
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Heat-resistant polyimidazolones were prepared by a two-step polycondensation of α-hydroxy ketones, aromatic diamines, and aromatic diisocyanates. By variation of the reactants several polymers of this type were prepared and their properties are described. Flexible films were cast from solution and parts were produced by moulding at 350°C.
    Notes: In einer zweistufigen Polykondensationsreaktion wurden aus α-Hydroxyketonen, aromatischen Diaminen und aromatischen Diisocyanaten hochtemperaturbeständige Polyimidazolone hergestellt. Durch Variation der Ausgangskomponenten wurde eine Reihe von Polymeren dieser Verbindungsklasse erhalten und in ihren Eigenschaften beschrieben. Aus Lösung wurden Filme gegossen, durch Heißpressen bei 350°C Formkörper hergestellt.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 214 (1933), S. 33-43 
    ISSN: 0863-1786
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Darstellung von reinem Schwefelmonoxyd bei höheren Drucken wird beschrieben und seine stöchiometrische Zusammensetzung durch Elementaranalyse der Formel SO entsprechend ermittelt.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 25 (1996), S. 486-500 
    ISSN: 0887-3585
    Keywords: protein-DNA interaction ; DNA bending ; helix-turn-helix ; Poisson-Boltzmann electrostatics ; docking ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A method is presented to predict overall conformations of protein-DNA complexes on the basis of the known three-dimensional structures of the proteins. The method is restricted to proteins with a common twofold symmetry axis, which show only minor conformational changes upon binding to DNA. The method uses a numerical finite difference solution of the linearized Poisson-Boltzmann equation and subsequent energy minimization cycles. Structural parameters - the rotation angle of the DNA relative to the protein around the common symmetry axis, the protein-DNA distance, and intermolecular hydrogen-bonding contacts - are presented for two test cases, DNA bound to CAP (catabolite gene activator protein) and to the Cro-repressor of bacteriophage 434. The DNA curvature in the starting model of the docking procedure was chosen as a smoothed approximation of the conformation found in the X-ray structures of these complexes. The method is further used to predict the unknown structure of the complex between the factor for inversion stimulation (FIS) and DNA, which is bent upon binding to FIS. In contrast to the test cases, the unknown curvature of the starting model is derived from a calibration of electrostatic precalculations for different proteins according to crystallographically observed DNA bending. The results of the modeling are in good accordance with the experimentally observed overall structure of protein-DNA complexes for the two test cases; for FIS, they correspond to several of the experimentally proposed protein-DNA contacts. © 1996 Wiley-Liss, Inc.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 30 (1987), S. 514-520 
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A mathematical model describing the affinity partitioning of macromolecules in aqueous two-phase systems has been derived. The model was used to calculate binding parameters that were compared against values deter mined by means of ultracentrifugation and fluorescence titration. The mathematical model and its modifications were found to describe satisfactorily the partition behavior of macromolecules with differing numbers of binding sites. It could be shown that in solutions containing PEG the binding behavior of FDH is changed fundamentally. The dissociation constants of FDH with PEG-blue in the presence and absence of PEG are different.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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