ISSN:
1420-9071
Keywords:
Key words. Myoglobin; oxygen transport; heart; skeletal muscle; transgenic mice.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract. Hemoproteins are widely distributed among prokaryotes, unicellular eukaryotes, plants and animals . Myoglobin, a cytoplasmic hemoprotein that is restricted to cardiomyocytes and oxidative skeletal myofibers in vertebrates, has been proposed to facilitate oxygen transport to the mitochondria . This cytoplasmic hemoprotein was the first protein to be subjected to definitive structural analysis and has been a subject of long-standing and ongoing interest to biologists . Recently, we utilized gene disruption technology to generate mice that are viable and fertile despite a complete absence of myoglobin . This unexpected result led us to reexamine existing paradigms regarding the function of myoglobin in striated muscle.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/PL00000732
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