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  • 1
    Electronic Resource
    Electronic Resource
    Hydrodynamic properties of solubilized (Na^+ + K^+)-ATPase from rectal glands of Squalus acanthias
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 603 (1980), S. 1-12 
    Details
    ISSN: 0005-2736
    Keywords: (Na^+ + K^+)-ATPase ; (Rectal gland) ; Detergent solubilization ; Glycerol protection
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2736(80)90386-7
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of transdermal l7β-estradiol and oral conjugated equine estrogens on biochemical parameters of bone resorption in natural menopause (1993)
    Springer
    Calcified tissue international 53 (1993), S. 13-16 
    Details
    ISSN: 1432-0827
    Keywords: Osteoporosis ; Menopause ; Estrogen ; Pyridinoline ; Bone resorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Objective: To evaluate and compare the effects or oral and transdermal estrogen replacement therapy on biochemical markers of bone resorption in early postmenopausal women Design: Controlled, randomized group comparison. Setting: Outpatient clinic for menopausal women and research into osteoporosis. Subjects: Sixty healthy women menopausal for less than 5 years and who had never received any medications interfering with bone metabolism. Interventions: The 60 women were randomly allocated to 3 months therapy with either oral conjugated estrogens (0.625 mg/day) (n = 28) or transdermal estradiol (50 jig/day) (n = 32) in cyclical combination with medroxyprogesterone acetate (5 mg/day). Main outcome measures: Traditional (urinary calcium/creatinine and hydroxyproline/creatinine) and the new specific (urinary pyridinoline/creatinine and deoxypyridinoline/creatinine) markers of bone resorption were determined before and after 3 months of treatment. Results: In both groups, circulating levels of estrone and estradiol were significantly (P 〈 0.001) increased during treatment. In women treated with oral conjugated equine estrogens, urinary calcium/creatinine and hydroxyproline/creatinine ratios were significantly (P 〈 0.05) reduced. Pyridinoline/creatinine ratio fell from 69.1 (4) [mean (SEM)] to 50 (4) μmol/μmol (P 〈 0.01) and deoxypyridinoline/creatinine ratio fell from 10.8 (1) [mean (SEM)] to 8.3 (0.8) μmol/μmol (P 〈 0.01). In the group treated with transdermal estradiol, urinary hydroxyproline/creatinine ratio was significantly (P 〈 0.05) reduced. Pyridinoline/creatinine ratio fell from 66.3 (4) [mean (SEM)] to 46.2 (3) μmol/μmol (P 〈 0.01) and deoxypyridinoline/creatinine ratio fell from 11.5 (1.5) [mean (SEM)] to 7.7 (0.6) μmol/μmol (P 〈 0.01). There were no differences between the evolution of the biochemical variables in the two groups. Conclusion: These results suggest that oral conjugated equine estrogens and transdermal estradiol, in the given doses, are equally effective in reducing postmenopausal bone resorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01352008
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of the menopause and hormone replacement therapy on the carboxy-terminal pyridinoline cross-linked telopeptide of type I collagen (1994)
    Springer
    Osteoporosis international 4 (1994), S. 349-352 
    Details
    ISSN: 1433-2965
    Keywords: Collagen ; Hormone replacement therapy ; Menopause ; Oestrogen ; Osteoporosis ; Procollagen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the effect of the menopause and postmenopausal hormone replacement therapy (HRT) on the serum concentration of carboxy-terminal pyridinoline cross-linked telopeptide of type I collagen (ICTP), a potential new biochemical marker of bone resorption. A group of 44 healthy postmenopausal women, aged 45–54 years, had about 19% higher serum ICTP than did a group of 42 healthy premenopausal women aged 35–50 years (3.6±0.8 µg/l v 3.0±0.7 µg/l (mean ±SD);p〈0.01), although there was a large overlap in the values. The 44 postmenopausal women also participated in a longitudinal clinical study, in which 20 received HRT and 24 received a placebo. Compared with the placebo group, those who received HRT had a significant (p〈0.05) decrease in ICTP of about 12% at the end of 1 year of treatment, but again there was considerable overlap in the values. The menopause-and HRT-induced changes in ICTP were less than those seen in serum osteocalcin, serum total alkaline phosphatase, and fasting urinary excretion of hydroxyproline, calcium, pyridinoline and deoxypyridinoline. We conclude that the menopause increases and HRT decreases ICTP, although these changes are less pronounced than those seen in other biochemical markers of bone turnover.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01622196
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of the menopause and hormone replacement therapy on serum carboxyterminal propeptide of type I collagen (1993)
    Springer
    Osteoporosis international 3 (1993), S. 50-52 
    Details
    ISSN: 1433-2965
    Keywords: Collagen ; Gestogen ; Menopause ; Oestrogen ; Osteoporosis ; Procolgen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the effect of the menopause and postmenopausal hormone replacement therapy on the serum concentration of carboxyterminal propeptide of type I procollagen (PICP), which is a biochemical marker of type I collagen synthesis. A group of 124 healthy postmenopausal women, aged 45–53 years, had about 20% higher serum PICP than did a group of 40 healthy premenopausal women aged 35–52 years (114±35 µg/1 vs. 95±26 µg/l (mean ± SD);p=0.002). The 124 postmenopausal women were also participating in a double-masked longitudinal study with two placebo groups and four different hormone replacement therapy groups. The four hormone regimens resulted in similar responses in serum PICP. Compared with placebo, 1 year of treatment with any of the four hormone replacement therapies significantly decreased serum PICP to premenopausal levels. We conclude that the formation of type I collagen is increased shortly after the menopause and that hormone replacement therapy reverses this increase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01623177
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    Paper (German National Licenses)
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