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  • 05 C 55  (1)
  • Paradoxical sleep  (1)
  • 1
    ISSN: 1432-1106
    Keywords: MPTP ; Paradoxical sleep ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a previous study, we reported on a selective and long-lasting paradoxical sleep (PS) deprivation in cats following repeated administration of the Parkinson syndrome-inducing neurotoxin N-methyl-4-pheny11,2,3,6-tetrahydropyridine (MPTP). While the characteistic motor deficits occurred only from the 2nd to 3rdday of a 5-day long administration of 5 mg/kg per day MPTP i.p., the PS deprivation started immediately after the first injection and lasted altogether for 11–13 days. The motor deficiencies induced by repeated administration of MPTP are mainly due to the selective depletion of dopaminergic neurons in the nigrostriatal system as the histological and biochemical data show. The immediate onset of PS deprivation and the PS recovery, despite the definite cell loss, suggests a mechanism independent of cell destruction. In our present study we investigated the occasional histological and the PS-deprivatory effect of a single low dose of MPTP in cats. A single injection of 2 mg/kg MPTP i.p. resulted in PS deprivation lasting for 2.5–3.5 h. The duration of other sleep stages showed no significant change and PS recovery was without rebound phenomenon, as in the case of repeated administration. Even a higher single dose of MPTP (5 mg/kg) resulted in no visibly detectable nigrostriatal cell loss. We suggest that the changes in monoamine release and/or turnover are involved in the PS deprivatory effect of MPTP.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1439-6912
    Keywords: 05 C 35 ; 05 C 55
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract This paper is a continuation of [10], where P. Erdős, A. Hajnal, V. T. Sós, and E. Szemerédi investigated the following problem: Assume that a so called forbidden graphL and a functionf(n)=o(n) are fixed. What is the maximum number of edges a graphG n onn vertices can have without containingL as a subgraph, and also without having more thanf(n) independent vertices? This problem is motivated by the classical Turán and Ramsey theorems, and also by some applications of the Turán theorem to geometry, analysis (in particular, potential theory) [27–29], [11–13]. In this paper we are primarily interested in the following problem. Let (G n ) be a graph sequence whereG n hasn vertices and the edges ofG n are coloured by the colours χ1,...,χ r so that the subgraph of colour χυ contains no complete subgraphK pv , (v=1,...r). Further, assume that the size of any independent set inG n iso(n) (asn→∞). What is the maximum number of edges inG n under these conditions? One of the main results of this paper is the description of a procedure yielding relatively simple sequences of asymptotically extremal graphs for the problem. In a continuation of this paper we shall investigate the problem where instead of α(G n )=o(n) we assume the stronger condition that the maximum size of aK p -free induced subgraph ofG n iso(n).
    Type of Medium: Electronic Resource
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