ISSN:
0009-2940
Keywords:
1,2,4-Oxadiazoles, 5-substituted, 3-(2-aminobenzyl)-
;
Indoles, 2-(acylamino)-
;
8H-Pyrimido[1,6-a: 4,5-b']diindoles, 6-aryl
;
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Catalytic hydrogenation of 5-substituted 3-(2-aminobenzyl)-1,2,4-oxadiazoles 7 give 2-(acylamino)indoles 10. Treatment of 2-(benzoylamino)indoles 10a-c with acid leads to the novel 6-phenyl-8H-pyrimido[1,6-a: 4,5-b']diindoles 19a-c. A route for the new ring formation is proposed. Catalytic hydrogenation of 19a (Raney nickel, 70°C, atmospheric pressure) saturates the 6-phenyl ring but leaves the pentacyclic ring system intact. The structure of 19a is confirmed by an X-ray crystallographic analysis.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19931260814
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