ISSN:
1420-9071
Schlagwort(e):
Aldose reductase inhibitors
;
1,2,4-triazolidine-3,5-diones
;
3,5-isoxazolidinediones
;
diabetes
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
,
Medizin
Notizen:
Abstract 1,2,4-Triazolidine-3,5-diones and the 3,5-isoxazolidinedione were, observed to be, potent inhibitors of rat lens aldose reductase activity. In vivo in streptozotocin-diabetic rats, selected agents at 20 mg/kg/day, orally for 21 days reduced significantly the sorbitol levels of rbc, lens and sciatic nerves, suggesting that these derivatives may have some usefulness to treat clinical complications of diabetes mellitus.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01923435
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